Marroquin Talia Yolanda, Guauque-Olarte Sandra
GIOD group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Pasto, Colombia.
GIOM group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Envigado, Colombia.
Jpn Dent Sci Rev. 2023 Dec;59:8-22. doi: 10.1016/j.jdsr.2022.12.001. Epub 2023 Jan 9.
The mechanisms modulated by periodontal pathogens in atherosclerosis are not fully understood. Aim: to perform an integrative analysis of gene and protein expression modulated by periodontal pathogens in cells and animal models for atherosclerosis.
Cochrane, PRISMA and AMSTAR2 guidelines for systematic reviews were followed. Data search was conducted in Pub-med, LILACS and Science Direct databases. Gene and protein expression data were collected from the included papers to perform an overrepresentation analysis using the Reactome Pathway Analysis tool and the KEGG database.
Thirty-two papers were included in the review, they analyzed the effect of , , , , , and or/and their virulent factors on gene and protein expression in human cells and animal models of atherosclerosis. Some of the modulated pathways include the immune system, programmed cell death, cellular responses to external stimuli, transport of small molecules, and signal transduction (p < 0.05). Those pathways are known to be involved in different stages of atherosclerosis progression.
Based on the performed analysis, it is possible to state that periodontal pathogens have the potential to be a contributing factor for atherosclerosis even in absence of a high-fat diet or high shear stress.
牙周病原体在动脉粥样硬化中所调节的机制尚未完全明确。目的：对牙周病原体在动脉粥样硬化细胞和动物模型中所调节的基因和蛋白质表达进行综合分析。
遵循Cochrane、PRISMA和AMSTAR2系统评价指南。在PubMed、LILACS和Science Direct数据库中进行数据检索。从纳入的论文中收集基因和蛋白质表达数据，使用Reactome通路分析工具和KEGG数据库进行过度表达分析。
该综述纳入了32篇论文，它们分析了[具体病原体名称未给出]及其毒力因子对动脉粥样硬化人类细胞和动物模型中基因和蛋白质表达的影响。一些被调节的通路包括免疫系统、程序性细胞死亡、细胞对外界刺激的反应、小分子转运和信号转导（p<0.05）。已知这些通路参与动脉粥样硬化进展的不同阶段。
基于所进行的分析，可以指出即使在没有高脂饮食或高剪切应力的情况下，牙周病原体也有可能成为动脉粥样硬化的一个促成因素。
Zotero 插件
