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Food Sci Nutr. 2022 Oct 13;11(1):569-577. doi: 10.1002/fsn3.3097. eCollection 2023 Jan.
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本文引用的文献

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Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study.生活方式、心血管代谢疾病与前瞻性中国研究中的多种共病。
Eur Heart J. 2021 Sep 7;42(34):3374-3384. doi: 10.1093/eurheartj/ehab413.
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Clinical management and treatment of obesity in China.中国肥胖的临床管理与治疗。
Lancet Diabetes Endocrinol. 2021 Jun;9(6):393-405. doi: 10.1016/S2213-8587(21)00047-4.
3
β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats.β-谷甾醇通过下调 2 型糖尿病大鼠脂肪细胞中 IKKβ/NF-κB 和 JNK 信号通路来规避肥胖引起的炎症和胰岛素抵抗。
Molecules. 2021 Apr 6;26(7):2101. doi: 10.3390/molecules26072101.
4
Phytosterols and their derivatives: Potential health-promoting uses against lipid metabolism and associated diseases, mechanism, and safety issues.植物固醇及其衍生物:在脂质代谢和相关疾病方面的潜在促进健康用途、作用机制和安全问题。
Compr Rev Food Sci Food Saf. 2020 Jul;19(4):1243-1267. doi: 10.1111/1541-4337.12560. Epub 2020 Jun 22.
5
Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders.植物甾醇:肥胖及其相关疾病管理中的营养健康要素
Antioxidants (Basel). 2020 Dec 12;9(12):1266. doi: 10.3390/antiox9121266.
6
Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.204 个国家和地区 1990-2019 年 87 种风险因素的全球负担:2019 年全球疾病负担研究的系统分析。
Lancet. 2020 Oct 17;396(10258):1223-1249. doi: 10.1016/S0140-6736(20)30752-2.
7
Stigmasterol stimulates transintestinal cholesterol excretion independent of liver X receptor activation in the small intestine.豆甾醇可刺激跨小肠胆固醇排泄,而不依赖于小肠中的肝 X 受体激活。
J Nutr Biochem. 2020 Feb;76:108263. doi: 10.1016/j.jnutbio.2019.108263. Epub 2019 Nov 9.
8
Possible anti-obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose-response meta-analysis of randomized controlled trials.植物固醇和植物甾烷醇补充剂对人体的可能抗肥胖作用:随机对照试验的系统评价和剂量反应荟萃分析。
Phytother Res. 2019 May;33(5):1246-1257. doi: 10.1002/ptr.6319. Epub 2019 Mar 5.
9
Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet.摄入豆甾醇和β-谷甾醇可改变高脂西式饮食喂养小鼠的脂代谢,减轻非酒精性脂肪性肝病。
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1274-1284. doi: 10.1016/j.bbalip.2018.08.004. Epub 2018 Aug 7.
10
Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera.鉴定辣木中 β-谷甾醇为体外抗炎成分。
J Agric Food Chem. 2018 Oct 17;66(41):10748-10759. doi: 10.1021/acs.jafc.8b04555. Epub 2018 Oct 3.

中国人群中膳食植物甾醇摄入量与肥胖患病率之间关系的性别差异。

Gender differences in the relationships between dietary phytosterols intake and prevalence of obesity in Chinese population.

作者信息

Guo Panpan, Feng Rennan, Li Zixiang, Han Ting

机构信息

Department of Clinical Nutrition Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.

Shanghai Clinical Nutrition Quality Control Center Shanghai China.

出版信息

Food Sci Nutr. 2022 Oct 13;11(1):569-577. doi: 10.1002/fsn3.3097. eCollection 2023 Jan.

DOI:10.1002/fsn3.3097
PMID:36655093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9834890/
Abstract

To investigate the associations between different phytosterols (PSs) intake and subtype of obesity in Chinese. Total 6073 adults aged ≥18 years was enrolled from China. General characteristics were completed by the validated dietary questionnaire. For total phytosterols intake, comparing Q4 with Q1 was inversely associated with the risks of overweight [odds ratio (OR) 95% confidence interval (CI), 0.82 (0.69, 0.96),  < .05]. The intake of stigmasterol, β-sitosterol, β-sitostanol and campestanol were associated with the lower risks of obesity, whereas no significant correlationss were found between campesterol intake and any subtype of obesity in the multivariable-adjusted model. Interestingly, the stigmasterol intake was inversely related with the prevalence of central obesity in female, while the β-sitostanol intake was found in male [OR 95% CI in Q3 of 0.78 (0.60-0.99) and 0.71 (0.56-0.91), respectively;  < .05]. The multiple linear regression models showed that fruits, vegetable-oil, nuts and seeds may be important diet sources of PSs. The intake of total PSs, β-sitosterol, stigmasterol, β-sitostanol and campestanol were inversely associated with the prevalence of obesity. Moreover, the lower obesity risk for total PSs and PSs subgroups differed for the gender. The firm results deserve to be further verified in cohort studies.

摘要

研究不同植物甾醇(PSs)摄入量与中国成年人肥胖亚型之间的关联。从中国招募了6073名年龄≥18岁的成年人。通过经过验证的饮食问卷收集一般特征。对于总植物甾醇摄入量,将第四分位数与第一分位数进行比较,与超重风险呈负相关[比值比(OR)95%置信区间(CI),0.82(0.69,0.96),P<0.05]。豆甾醇、β-谷甾醇、β-谷甾烷醇和菜油甾醇的摄入量与肥胖风险较低相关,而在多变量调整模型中,菜油甾醇摄入量与任何肥胖亚型之间均未发现显著相关性。有趣的是,豆甾醇摄入量与女性中心性肥胖患病率呈负相关,而男性则发现β-谷甾烷醇摄入量与之相关[第三分位数的OR 95%CI分别为0.78(0.60-0.99)和0.71(0.56-0.91);P<0.05]。多元线性回归模型显示,水果、植物油、坚果和种子可能是PSs的重要饮食来源。总PSs、β-谷甾醇、豆甾醇、β-谷甾烷醇和菜油甾醇的摄入量与肥胖患病率呈负相关。此外,总PSs和PSs亚组较低的肥胖风险在性别上存在差异。这些确凿的结果值得在队列研究中进一步验证。