Guo Panpan, Feng Rennan, Li Zixiang, Han Ting
Department of Clinical Nutrition Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Shanghai Clinical Nutrition Quality Control Center Shanghai China.
Food Sci Nutr. 2022 Oct 13;11(1):569-577. doi: 10.1002/fsn3.3097. eCollection 2023 Jan.
To investigate the associations between different phytosterols (PSs) intake and subtype of obesity in Chinese. Total 6073 adults aged ≥18 years was enrolled from China. General characteristics were completed by the validated dietary questionnaire. For total phytosterols intake, comparing Q4 with Q1 was inversely associated with the risks of overweight [odds ratio (OR) 95% confidence interval (CI), 0.82 (0.69, 0.96), < .05]. The intake of stigmasterol, β-sitosterol, β-sitostanol and campestanol were associated with the lower risks of obesity, whereas no significant correlationss were found between campesterol intake and any subtype of obesity in the multivariable-adjusted model. Interestingly, the stigmasterol intake was inversely related with the prevalence of central obesity in female, while the β-sitostanol intake was found in male [OR 95% CI in Q3 of 0.78 (0.60-0.99) and 0.71 (0.56-0.91), respectively; < .05]. The multiple linear regression models showed that fruits, vegetable-oil, nuts and seeds may be important diet sources of PSs. The intake of total PSs, β-sitosterol, stigmasterol, β-sitostanol and campestanol were inversely associated with the prevalence of obesity. Moreover, the lower obesity risk for total PSs and PSs subgroups differed for the gender. The firm results deserve to be further verified in cohort studies.
研究不同植物甾醇(PSs)摄入量与中国成年人肥胖亚型之间的关联。从中国招募了6073名年龄≥18岁的成年人。通过经过验证的饮食问卷收集一般特征。对于总植物甾醇摄入量,将第四分位数与第一分位数进行比较,与超重风险呈负相关[比值比(OR)95%置信区间(CI),0.82(0.69,0.96),P<0.05]。豆甾醇、β-谷甾醇、β-谷甾烷醇和菜油甾醇的摄入量与肥胖风险较低相关,而在多变量调整模型中,菜油甾醇摄入量与任何肥胖亚型之间均未发现显著相关性。有趣的是,豆甾醇摄入量与女性中心性肥胖患病率呈负相关,而男性则发现β-谷甾烷醇摄入量与之相关[第三分位数的OR 95%CI分别为0.78(0.60-0.99)和0.71(0.56-0.91);P<0.05]。多元线性回归模型显示,水果、植物油、坚果和种子可能是PSs的重要饮食来源。总PSs、β-谷甾醇、豆甾醇、β-谷甾烷醇和菜油甾醇的摄入量与肥胖患病率呈负相关。此外,总PSs和PSs亚组较低的肥胖风险在性别上存在差异。这些确凿的结果值得在队列研究中进一步验证。