Department of Dermatology, Adana Dr. Turgut Noyan Application and Research Center, Başkent University Faculty of Medicine, Adana, Turkey.
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Mycopathologia. 2023 Jan 19;188(1):2. doi: 10.1007/s11046-023-00708-2.
Fungal infections of the skin, nails, and hair caused by dermatophyte species continue to be a worldwide concern. The increase in terbinafine-resistant superficial dermatophytosis has become a major concern over the last decade. In this report, we presented two cases of infection with terbinafine-resistant Trichophyton indotineae, the first diagnosis of this species in Turkey. One patient exhibited erythematous pruritic patches and plaques in the inguinal and gluteal regions, while the other patient showed annular erythematous scaly plaques in the bilateral posterior thigh and gluteal regions. One patient harbored a CD36 mutation. Both strains harbored the same amino acid substitution in the squalene epoxidase gene, whereas one isolate had another unknown mutation. Clinical improvement was observed with resveratrol treatment in the patient with the CD36 mutation but not in the other patient.
皮肤、指甲和毛发的真菌感染由皮肤癣菌引起，仍是全球关注的问题。过去十年间，特比萘芬耐药的浅部皮肤真菌病的增加已成为一个主要关注点。在本报告中，我们报告了两例特比萘芬耐药的堇毛癣菌感染，这是该种在土耳其的首次诊断。一名患者表现为腹股沟和臀部的红斑性瘙痒斑块，另一名患者表现为双侧大腿后部和臀部的环状红斑鳞屑斑块。一名患者携带 CD36 突变。两株菌的角鲨烯环氧化酶基因均存在相同的氨基酸取代，而其中一株菌还有另一个未知的突变。携带 CD36 突变的患者经白藜芦醇治疗后临床改善，而另一名患者则没有。
