尼帕病毒的分子发病机制。

Molecular Pathogenesis of Nipah Virus.

机构信息

Department of Biotechnology, University of Engineering and Management, Kolkata University Area, Plot, Street Number 03, Action Area III, B/5, Newtown, Kolkata, West Bengal, 700156, India.

出版信息

Appl Biochem Biotechnol. 2023 Apr;195(4):2451-2462. doi: 10.1007/s12010-022-04300-0. Epub 2023 Jan 19.

Abstract

Viral diseases are causing mayhem throughout the world. One of the zoonotic viruses that have emerged as a potent threat to community health in the past few decades is Nipah virus. Nipah viral sickness is a zoonotic disease whose main carrier is bat. This disease is caused by Nipah virus (NiV). It belongs to the henipavirous group and of the family paramyxoviridae. Predominantly Pteropus spp. is the carrier of this virus. It was first reported from the Kampung Sungai Nipah town of Malaysia in 1998. Human-to-human transmission can also occur. Several repeated outbreaks were reported from South and Southeast Asia in the recent past. In humans, the disease is responsible for rapid development of acute illness, which can result in severe respiratory illness and serious encephalitis. Therefore, this calls for an urgent need for health authorities to conduct clinical trials to establish possible treatment regimens to prevent any further outbreaks.

摘要

病毒性疾病正在全世界造成严重破坏。在过去几十年中,作为对社区健康的潜在威胁而出现的人畜共患病病毒之一是尼帕病毒。尼帕病毒性疾病是一种人畜共患病,其主要载体是蝙蝠。这种疾病是由尼帕病毒(NiV)引起的。它属于亨德拉病毒科,副粘病毒科。主要的载体是果蝠属。它于 1998 年首次在马来西亚的 Kampung Sungai Nipah 镇报告。也可以发生人与人之间的传播。最近在南亚和东南亚有几次反复爆发的报道。在人类中,这种疾病会导致急性疾病迅速发展,可能导致严重的呼吸道疾病和严重的脑炎。因此,这迫切需要卫生当局进行临床试验,以建立可能的治疗方案,防止进一步爆发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8d/9869300/703d48cc8f9d/12010_2022_4300_Fig1_HTML.jpg

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