Yi Xin, Yuan Zhishan, Yu Xiao, Zheng Lijuan, Wang Chengyong
School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou510006, P. R. China.
Guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology, Guangdong University of Technology, Guangzhou510006, P. R. China.
ACS Appl Mater Interfaces. 2023 Feb 1;15(4):4873-4882. doi: 10.1021/acsami.2c17954. Epub 2023 Jan 19.
Pesticide residues are a global threat to human health, and conventional sensors fail to simultaneously detect pesticide residues on the surface and inside agricultural products. In this work, we present a new microneedle (MN) patch-based surface-enhanced Raman spectroscopy (SERS) sensor. The needles and the basement of MNs can simultaneously detect pesticide residues on the surface and inside agricultural products. The Ag nanoparticles and sodium hyaluronate/poly(vinyl alcohol) (HA/PVA) hydrogel used in this MN patch-based sensor efficiently amplify the Raman signals of the pesticide residues. In addition, the HA/PVA hydrogel can effectively and quickly collect the residues, allowing this sensor to detect pesticide residues more conveniently. Furthermore, the stepped structure of the MNs increases the sensor's surface area. Experimental results show that the sensor can detect thiram and thiabendazole (TBZ) pesticide residues with detection limits of 10 and 10 M, respectively. The detection process is minimally invasive and not harmful to agricultural products. The application of this MN patch-based SERS sensor can be extended to the safety and health monitoring of other plants and animals.
农药残留是对人类健康的全球性威胁，而传统传感器无法同时检测农产品表面和内部的农药残留。在这项工作中，我们展示了一种基于微针（MN）贴片的表面增强拉曼光谱（SERS）传感器。微针及其基底能够同时检测农产品表面和内部的农药残留。这种基于微针贴片的传感器中使用的银纳米颗粒和透明质酸钠/聚乙烯醇（HA/PVA）水凝胶能有效放大农药残留的拉曼信号。此外，HA/PVA水凝胶能够有效且快速地收集残留，使该传感器能更方便地检测农药残留。此外，微针的阶梯结构增加了传感器的表面积。实验结果表明，该传感器能够分别检测福美双和噻菌灵（TBZ）农药残留，检测限分别为10和10 M。检测过程微创且对农产品无害。这种基于微针贴片的SERS传感器的应用可扩展到其他动植物的安全与健康监测。
