Yan Haihan, Lang Junlian, Yan Shaoxiao, Wang Li, Liu Rui, Wang Nan, Xu Liangyuan, Guo Qihan, Ren Tingting, Yang Runzi, Zhang Yufei, Ke Feng, Ma Jianmin
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren hospital, Capital Medical University, Beijing, 100730, China.
Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
BMJ Open Ophthalmol. 2025 Jun 26;10(1):e001842. doi: 10.1136/bmjophth-2024-001842.
Orbital malignant tumours seriously affect the quality of life of patients; however, there is currently no quality-of-life questionnaire for patients with orbital malignant tumours.
To develop and evaluate a quality-of-life questionnaire for patients with orbital malignant tumours.
A pool of items was generated through a literature search, expert meeting and patient interview. Pre-survey and scale evaluation were performed, the quality-of-life questionnaire for patients with orbital malignant tumours (QLQ-OT) was modified, and the scale was evaluated by measuring the quality of life of 46 patients with orbital tumours.
The effective rate of QLQ-OT was 97.4%, the Cronbach's alpha coefficient was >0.6, and the test-retest reliability Intraclass Correlation Coefficient was >0.7, suggesting good internal consistency and test-retest reliability. The Pearson correlation coefficients were >0.8 between individual domain scores; > 0.6 between items and their own domains in the QLQ-OT; and >0.6 between domains and their corresponding domains in Quality of Life Center Questionnaire, thereby indicating good content, convergent and criterion-related validity. Ten principal components (the initial eigenvalues >1) were abstracted from 38 items of the general by factor analysis, accounting for 81.0% of cumulative variance.
QLQ-OT has good compliance, reliability, validity and responsiveness and can be used to measure the quality of life of patients with orbital malignant tumours.
眼眶恶性肿瘤严重影响患者的生活质量；然而，目前尚无针对眼眶恶性肿瘤患者的生活质量问卷。
研制并评价眼眶恶性肿瘤患者生活质量问卷。
通过文献检索、专家会议及患者访谈产生条目池。进行预调查和量表评价，对眼眶恶性肿瘤患者生活质量问卷（QLQ-OT）进行修改，并通过对46例眼眶肿瘤患者生活质量的测评对量表进行评价。
QLQ-OT有效率为97.4%，Cronbach's α系数>0.6，重测信度组内相关系数>0.7，提示具有良好的内部一致性和重测信度。各领域得分之间的Pearson相关系数>0.8；QLQ-OT中各条目与其所属领域之间的相关系数>0.6；生活质量中心问卷中各领域与其对应领域之间的相关系数>0.6，表明具有良好的内容效度、收敛效度和效标关联效度。通过因子分析从38个一般条目中提取出10个主成分（初始特征值>1），累计方差贡献率为81.0%。
QLQ-OT具有良好的依从性、信度、效度和反应度，可用于测评眼眶恶性肿瘤患者的生活质量。
