State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Institute of Biochemistry, Faculty of Biology and Chemistry, Justus Liebig University of Giessen, Giessen, Germany.
Nat Cell Biol. 2023 Jan;25(1):1-5. doi: 10.1038/s41556-022-01066-9.
Alternative splicing of eukaryotic transcripts often leads to production of multiple mature RNAs from a single gene locus. In addition to encoding linear RNAs, genes can produce stable circular RNAs (circRNAs) that are often co-expressed with their cognate linear RNAs. Multiple distinct circRNAs are frequently generated from a gene locus via back-splicing, with each mature transcript having a potentially unique function due to its distinct combination of exons and sometimes retained introns. However, names currently given to circRNAs are often ambiguous and lack consistency across studies. Here, we call on the community to embrace standards for naming circRNAs so that a common nomenclature is used to ensure clarity and reproducibility.
真核生物转录本的可变剪接通常会导致一个基因座产生多个成熟 RNA。除了编码线性 RNA 外，基因还可以产生稳定的环状 RNA (circRNA)，这些环状 RNA 通常与它们的同源线性 RNA 共表达。通过反向剪接，一个基因座可以产生多个不同的成熟 circRNA，每个成熟的转录本由于其独特的外显子组合，有时还包括保留的内含子，都具有潜在独特的功能。然而，目前给 circRNA 起的名字往往不够明确，而且在不同的研究中缺乏一致性。在这里，我们呼吁研究界采用 circRNA 的命名标准，以便使用通用的命名法来确保清晰性和可重复性。
