Zhai Qixiao, Li Tianqi, Yu Leilei, Xiao Yue, Feng Saisai, Wu Jiangping, Zhao Jianxin, Zhang Hao, Chen Wei
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; UK-China Joint Centre on Probiotic Bacteria, Norwich, UK and Wuxi, China.
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Sci Bull (Beijing). 2017 Jun 30;62(12):831-840. doi: 10.1016/j.scib.2017.01.031. Epub 2017 Jan 25.
Oral exposure to toxic metals such as cadmium (Cd), lead (Pb), copper (Cu) and aluminum (Al) can induce various adverse health effects in humans and animals. However, the effects of these metals on the gut microbiota have received limited attention. The present study demonstrated that long-term toxic metal exposure altered the intestinal microbiota of mice in a metal-specific and time-dependent manner. Subchronic oral Cu exposure for eight weeks caused a profound decline in gut microbial diversity in mice, whereas no significant changes were observed in groups treated with other metals. Cd exposure significantly increased the relative abundances of organisms from the genera Alistipes and Odoribacter and caused marked decreases in Mollicutes and unclassified Ruminococcaceae. Pb exposure significantly decreased the abundances of eight genera: unclassified and uncultured Ruminococcaceae, unclassified Lachnospiraceae, Ruminiclostridium_9, Rikenellaceae_RC9_gut_group, Oscillibacter, Anaerotruncus and Lachnoclostridium. Cu exposure affected abundances of the genera Alistipes, Bacteroides, Ruminococcaceae_UCG-014, Allobaculum, Mollicutes_RF9_norank, Rikenellaceae_RC9_gut_group, Ruminococcaceae_unclassified and Turicibacter. Al exposure increased the abundance of Odoribacter and decreased that of Anaerotruncus. Exposure to any metal for eight weeks significantly decreased the abundance of Akkermansia. These results provide a new understanding regarding the role of toxic metals in the pathogenesis of intestinal and systemic disorders in the host within the gut microbiota framework.
经口暴露于镉（Cd）、铅（Pb）、铜（Cu）和铝（Al）等有毒金属可在人和动物身上引发各种不良健康影响。然而，这些金属对肠道微生物群的影响受到的关注有限。本研究表明，长期暴露于有毒金属会以金属特异性和时间依赖性方式改变小鼠的肠道微生物群。亚慢性经口暴露于铜8周导致小鼠肠道微生物多样性显著下降，而其他金属处理组未观察到显著变化。镉暴露显著增加了Alistipes属和Odoribacter属微生物的相对丰度，并导致柔膜菌纲和未分类的瘤胃球菌科显著减少。铅暴露显著降低了8个属的丰度：未分类和未培养的瘤胃球菌科、未分类的毛螺菌科、瘤胃梭菌属9、理研菌科RC9肠道菌群、颤杆菌属、厌氧短杆菌属和粪球菌属。铜暴露影响了Alistipes属、拟杆菌属、瘤胃球菌科UCG-014、全杆菌属、柔膜菌纲RF9无分类等级、理研菌科RC9肠道菌群、未分类的瘤胃球菌科和Turicibacter属的丰度。铝暴露增加了Odoribacter属的丰度，降低了厌氧短杆菌属的丰度。暴露于任何一种金属8周均显著降低了Akkermansia属的丰度。这些结果为有毒金属在肠道微生物群框架内宿主肠道和全身疾病发病机制中的作用提供了新的认识。
