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三种新的贝壳杉烷二萜类化合物来自佛肚树的根及其对人肿瘤细胞系的细胞毒性。

Three new ent-abietane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxicity in human tumor cell lines.

机构信息

Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

出版信息

Arch Pharm Res. 2019 Jun;42(6):512-518. doi: 10.1007/s12272-019-01151-y. Epub 2019 Apr 17.

DOI:10.1007/s12272-019-01151-y
PMID:30997601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6562045/
Abstract

Three new ent-abietane diterpenoids, termed fischerianoids A-C (1-3), were isolated and identified from the ethyl acetate extracts of roots of the medicinally valuable plant Euphorbia fischeriana. The planar and relative structures of 1-3 were established via high-resolution electrospray ionisation mass spectrometry and one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, and the absolute configuration of 1 was further established via X-ray crystallography experiment. Compounds 1-3 showed selective inhibitory potency against certain human tumor cell lines with IC values ranging from 8.50 ± 0.13 to 35.52 ± 0.08 μM.

摘要

从药用植物大飞扬根的乙酸乙酯提取物中分离得到三种新的-ent-贝壳杉烷二萜，分别命名为 Fischerianoids A-C（1-3）。通过高分辨电喷雾电离质谱和一维、二维核磁共振波谱分析确定了 1-3 的平面和相对结构，并通过 X 射线晶体学实验进一步确定了 1 的绝对构型。化合物 1-3 对某些人肿瘤细胞系具有选择性抑制活性，IC 值范围为 8.50±0.13 至 35.52±0.08μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/d48aca5676ab/12272_2019_1151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/a0fff8cc113e/12272_2019_1151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/55902bf03594/12272_2019_1151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/d48aca5676ab/12272_2019_1151_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/a0fff8cc113e/12272_2019_1151_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/55902bf03594/12272_2019_1151_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4257/6562045/d48aca5676ab/12272_2019_1151_Fig3_HTML.jpg

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