Anestad G, Lunde O, Moen M, Dalaker K
Department of Virology, National Institute of Public Health, Oslo, Norway.
Fertil Steril. 1987 Nov;48(5):787-90. doi: 10.1016/s0015-0282(16)59531-4.
The prevalence of humoral IgG and IgM antibodies to Chlamydia trachomatis was determined in 105 infertile women who underwent laparoscopy and/or laparatomy, and 90 pregnant women without any known fertility problems (control group). For chlamydial culture, cervical and urethral specimens were collected both from the infertile and the pregnant women, whereas specimens from the fallopian tubes were collected from the infertile women only. Among infertile subjects with abnormal fallopian tube findings, the prevalence of IgG as well as IgM antibodies to C. trachomatis was significantly higher than in the control group (P less than or equal to 0.001). Similar statistically significant differences in antichlamydial geometric mean titer (GMT) also were observed in sera from infertile subjects with fallopian tube abnormalities and the controls. The chlamydial isolation rate from lower genital samples was low both among the infertile and pregnant women. All tubal samples were culture negative. The present study indicates a close connection between infertility of tubal etiology and an immune response to C. trachomatis. The possibility of active or recent chlamydial activity in at least some of these infertile subjects is discussed.
在105名接受腹腔镜检查和/或剖腹手术的不孕妇女以及90名无任何已知生育问题的孕妇（对照组）中，测定了沙眼衣原体的体液IgG和IgM抗体的流行率。对于衣原体培养，从不孕妇女和孕妇中均采集宫颈和尿道标本，而仅从不孕妇女中采集输卵管标本。在输卵管检查结果异常的不孕受试者中，沙眼衣原体IgG和IgM抗体的流行率显著高于对照组（P≤0.001）。在输卵管异常的不孕受试者和对照组的血清中，抗衣原体几何平均滴度（GMT）也观察到类似的统计学显著差异。不孕妇女和孕妇中来自下生殖道样本的衣原体分离率均较低。所有输卵管样本培养均为阴性。本研究表明输卵管病因性不孕与对沙眼衣原体的免疫反应之间存在密切联系。讨论了至少其中一些不孕受试者中存在活动性或近期衣原体感染的可能性。
