Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut 71524, Egypt.
Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan.
J Asian Nat Prod Res. 2022 Aug;24(8):794-802. doi: 10.1080/10286020.2021.1979522. Epub 2021 Sep 29.
The ethyl acetate and dichloromethane-soluble fractions, from a soft coral total methanolic extract, exhibited significant anti-leishmanial and cytotoxic activities. These active fractions yielded a new cembranoid diterpene (), two known analogues [sarcotrocheliol () and sarcophine ()], and two sterols [(24)-24-methylcholesterol () and gorgosterol ()]. The structure of the new diterpene () was determined via a detailed analysis of its spectroscopic data. Compounds and demonstrated noticeable cytotoxicity on A549 (IC 17.4 ± 1.9 µg/ml) and HepG2 (IC 17.7 ± 1.5 µg/ml) cell lines, respectively. None of the isolates showed detectable anti-leishmanial activity (IC >100 µg/ml).
从软珊瑚总甲醇提取物的乙酸乙酯和二氯甲烷可溶部分中，发现了具有显著抗利什曼原虫和细胞毒性的活性成分。这些活性部分产生了一种新的海松烷二萜（）、两种已知的类似物[沙罗曲醇（）和沙罗菲因（）]和两种甾醇[（24）-24-甲基胆固醇（）和戈尔戈固醇（）]。新二萜（）的结构通过对其光谱数据的详细分析确定。化合物和分别对 A549（IC 17.4±1.9µg/ml）和 HepG2（IC 17.7±1.5µg/ml）细胞系表现出显著的细胞毒性。分离物中没有一种显示出可检测的抗利什曼原虫活性（IC >100µg/ml）。
