State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, China.
Mar Drugs. 2023 Jan 20;21(2):69. doi: 10.3390/md21020069.
The present investigation of the South China Sea soft coral resulted in the discovery of six new polyoxygenated diterpenes, namely sartrocheliols A-E (, , -) along with four known ones, , , , and . Based on extensive spectroscopic data analysis, sartrocheliol A () was identified as an uncommon capnosane diterpene, while sartrocheliols B-E (, -) were established as cembrane diterpenes. They displayed diverse structural features not only at the distinctly different carbon frameworks but also at the various types of heterocycles, including the epoxide, γ-lactone, furan, and pyran rings. Moreover, their absolute configurations were determined by a combination of quantum mechanical-nuclear magnetic resonance (QM-NMR) approach, modified Mosher's method, and X-ray diffraction analysis. In the anti-tumor bioassay, compound exhibited moderate cytotoxic activities against A549, H1975, MDA-MB-231, and H1299 cells with the IC values ranging from 26.3 to 47.9 μM.
本研究对南海软珊瑚进行了调查，从中发现了六种新的多氧化二萜，分别为 sartrocheliols A-E（1-6），以及四种已知的化合物 、 、 、 。通过广泛的光谱数据分析，确定 sartrocheliol A（1）为一种不常见的碳烷二萜，而 sartrocheliols B-E（2-6）则被确定为枞烷二萜。它们不仅在明显不同的碳骨架上，而且在各种类型的杂环，包括环氧化物、γ-内酯、呋喃和吡喃环上，显示出不同的结构特征。此外，它们的绝对构型是通过量子力学-核磁共振（QM-NMR）方法、改进的 Mosher 方法和 X 射线衍射分析相结合确定的。在抗肿瘤生物测定中，化合物 6 对 A549、H1975、MDA-MB-231 和 H1299 细胞表现出中等的细胞毒性活性，IC 值范围为 26.3-47.9 μM。
