Cordaro Marika, D'Amico Ramona, Fusco Roberta, Genovese Tiziana, Peritore Alessio Filippo, Gugliandolo Enrico, Crupi Rosalia, Di Paola Davide, Interdonato Livia, Impellizzeri Daniela, Cuzzocrea Salvatore, Di Paola Rosanna, Siracusa Rosalba
Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Antioxidants (Basel). 2022 Dec 25;12(1):40. doi: 10.3390/antiox12010040.
Parkinson's disease (PD) is a dopaminergic neuron-related neurodegenerative illness. Treatments exist that alleviate symptoms but have a variety of negative effects. Recent research has revealed that oxidative stress, along with neuroinflammation, is a major factor in the course of this disease. Therefore, the aim of our study was to observe for the first time the effects of a natural compound such as L. rhizome in an in vivo model of PD induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). For the study, mice received four injections of MPTP (20 mg/kg) for the induction of PD. Starting 24 h after the first administration of MPTP we treated mice with L. rhizome (100 mg/kg) daily for seven days. Our findings clearly demonstrated that L. rhizome treatment decreases oxidative stress by activating redox balance enzymes such as Nrf2/HO-1. We also demonstrated that L. rhizome is capable of modulating inflammatory indicators involved in PD, such as IκB-α, NF-κB, GFAP and Iba1, thus reducing the degeneration of dopaminergic neurons and motor and non-motor alterations. To summarize, L. rhizome, which is subject to fewer regulations than traditional medications, could be used as a dietary supplement to improve patients' brain health and could be a promising nutraceutical choice to slow the course and symptoms of PD.
帕金森病（PD）是一种与多巴胺能神经元相关的神经退行性疾病。现有的治疗方法可以缓解症状，但有多种负面影响。最近的研究表明，氧化应激与神经炎症一起，是这种疾病病程中的一个主要因素。因此，我们研究的目的是首次观察天然化合物如L.根茎在神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的帕金森病体内模型中的作用。在该研究中，小鼠接受四次MPTP注射（20 mg/kg）以诱导帕金森病。在首次给予MPTP后24小时开始，我们每天用L.根茎（100 mg/kg）治疗小鼠，持续七天。我们的研究结果清楚地表明，L.根茎治疗通过激活Nrf2/HO-1等氧化还原平衡酶来降低氧化应激。我们还证明，L.根茎能够调节帕金森病中涉及的炎症指标，如IκB-α、NF-κB、GFAP和Iba1，从而减少多巴胺能神经元的退化以及运动和非运动改变。总之，与传统药物相比受到较少监管的L.根茎，可以用作膳食补充剂来改善患者的大脑健康，并且可能是减缓帕金森病病程和症状的一种有前途的营养保健品选择。
