Paulitsch-Fuchs Astrid H, Melchior Nadine, Haitzmann Theresa, Fingerhut Theres, Feierl Gebhard, Baumert Rita, Kittinger Clemens, Zarfel Gernot
Biomedical Science, School of Health Sciences and Social Work, Carinthia University of Applied Sciences, St. Veiterstraße 47, 9020 Klagenfurt, Austria.
Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Antibiotics (Basel). 2022 Dec 20;12(1):1. doi: 10.3390/antibiotics12010001.
Extended spectrum beta lactamases producing Enterobacteriaceae are a major player in the antibiotic resistance challenge. In general, the situation regarding antibiotic resistance in Austria is very good compared to many other countries. Perhaps this is why there is a lack of data on the distribution of ESBL genes in the clinical setting. The aim of this study was to collect data on ESBL genes from a larger sample of human non-invasive clinical isolates from one region in Austria. In total, 468 isolates from different sample materials isolated at the Medical University of Graz from 2017 were examined. The most frequent organisms were and . Among the enzymes produced, CTX-M-15 was clearly dominant, exotic ESBLs were only represented by three isolates harboring genes for VEB-6 and one for CTX-M-2, respectively. Compared to other countries, the results are in line with the expectations. The data help to better classify the many studies from the non-clinical field in Austria and to shift the focus slightly away from the exotic results and sample sites.
产超广谱β-内酰胺酶的肠杆菌科细菌是抗生素耐药性挑战中的主要因素。总体而言，与许多其他国家相比，奥地利的抗生素耐药情况非常良好。也许这就是为什么在临床环境中缺乏超广谱β-内酰胺酶（ESBL）基因分布数据的原因。本研究的目的是从奥地利一个地区的大量人类非侵入性临床分离株样本中收集ESBL基因数据。总共检查了2017年在格拉茨医科大学分离的来自不同样本材料的468株分离株。最常见的菌株是 和 。在所产生的酶中，CTX-M-15明显占主导地位，外来ESBL分别仅由三株携带VEB-6基因的 分离株和一株携带CTX-M-2基因的 分离株代表。与其他国家相比，结果符合预期。这些数据有助于更好地对奥地利非临床领域的众多研究进行分类，并将重点从外来结果和样本地点稍微转移开。
