Schweigerer L, Neufeld G, Gospodarowicz D
Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
Invest Ophthalmol Vis Sci. 1987 Nov;28(11):1838-43.
Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.
培养的人视网膜母细胞瘤细胞表达碱性成纤维细胞生长因子（bFGF）基因，并且它们产生的物质即便与bFGF不完全相同，也极为相似。源自视网膜母细胞瘤的bFGF能够刺激毛细血管内皮细胞的增殖，而这一过程会被抗bFGF抗体所抑制。可以想象，源自视网膜母细胞瘤的bFGF促成了视网膜母细胞瘤的新生血管形成。
