Wang Lang, Wei Can, Jing Junfeng, Ni Dawei, Shao Mingmin, Chen Jingxiong, Wu Wei, Zhang Yanbin
The Second People's Hospital of Hefei, Hefei, China.
The Fifth Clinical School of Medicine, Anhui Medical University, Hefei, China.
Front Nutr. 2025 Jun 3;12:1538874. doi: 10.3389/fnut.2025.1538874. eCollection 2025.
Inflammation and oxidative stress are a common and fundamental factor in the pathological process leading to erectile dysfunction (ED) and metabolic dysregulation. We aimed to reveal the relationship between the DII, composite dietary antioxidant index (CDAI), and ED, as well as the mediating role of MS, TyG index, MAP, UA, and TC on this relationship.
This study included 1,488 participants from the NHANES surveys conducted between 2001 and 2004. The DII was constructed using 27 dietary components related to inflammatory potential, while the CDAI was built using six key minerals and vitamins. In the analysis, Spearman correlation, generalized linear models, and weighted logistic regression models were employed. The mediating roles of metabolic indicators in the relationships were investigated using Causal mediation analysis.
After comprehensive adjustment for confounding factors, we found a significant association between DII (OR: 1.07, 95% CI: 1.03-1.11, < 0.001) and CDAI (OR: 0.97, 95% CI: 0.95-1.00, < 0.05) and ED. Additionally, all metabolic indicators except for the TyG index (OR: 1.54, 95% CI: 1.20-1.96, < 0.01), did not show a significant association with the risk of ED. The DII + CDAI group had the highest ED risk. Further mediation analysis indicated that TyG played a mediating role between DII and ED, while MS played a mediating role between CDAI and ED.
This study indicates that DII and CDAI were significantly associated with ED.
炎症和氧化应激是导致勃起功能障碍（ED）和代谢失调的病理过程中的常见且基本因素。我们旨在揭示饮食炎症指数（DII）、复合膳食抗氧化指数（CDAI）与ED之间的关系，以及代谢综合征（MS）、甘油三酯葡萄糖指数（TyG指数）、平均动脉压（MAP）、尿酸（UA）和总胆固醇（TC）在此关系中的中介作用。
本研究纳入了2001年至2004年间进行的美国国家健康与营养检查调查（NHANES）中的1488名参与者。DII是使用27种与炎症潜力相关的膳食成分构建的，而CDAI是使用六种关键矿物质和维生素构建的。在分析中，采用了Spearman相关性分析、广义线性模型和加权逻辑回归模型。使用因果中介分析研究代谢指标在这些关系中的中介作用。
在对混杂因素进行全面调整后，我们发现DII（比值比：1.07，95%置信区间：1.03 - 1.11，P < 0.001）和CDAI（比值比：0.97，95%置信区间：0.95 - 1.00，P < 0.05）与ED之间存在显著关联。此外，除TyG指数外（比值比：1.54，95%置信区间：1.20 - 1.96，P < 0.01），所有代谢指标与ED风险均未显示出显著关联。DII + CDAI组的ED风险最高。进一步的中介分析表明，TyG在DII与ED之间起中介作用，而MS在CDAI与ED之间起中介作用。
本研究表明DII和CDAI与ED显著相关。
