Huang Jiahuan, Ren Wenbo, Hu Weishang, Ni Jianfang
Geriatric Medicine Center, Department of Geriatric Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Open Life Sci. 2025 Jun 12;20(1):20251123. doi: 10.1515/biol-2025-1123. eCollection 2025.
In recent years, there has been a notable increase in the prevalence of tumors and tuberculosis (TB), particularly among elderly and immunocompromised populations. Early diagnosis and treatment are crucial for significantly improving patient outcomes. However, traditional diagnostic methods exhibit certain limitations. The rapid advancement of metagenomic next-generation sequencing (mNGS) has shown promising applications in the field of infectious diseases. We describe an 88-year-old male with multiple comorbidities, including newly diagnosed localized prostate cancer, who presented asymptomatically. Routine mNGS screening unexpectedly identified , suggesting that malignancy may foster immune conditions favoring latent TB reactivation. This case emphasizes mNGS's role as a rapid, sensitive diagnostic adjunct for occult infections in high-risk populations.
近年来，肿瘤和结核病（TB）的患病率显著上升，尤其是在老年和免疫功能低下人群中。早期诊断和治疗对于显著改善患者预后至关重要。然而，传统诊断方法存在一定局限性。宏基因组下一代测序（mNGS）的快速发展在传染病领域显示出了有前景的应用。我们描述了一名88岁男性，患有多种合并症，包括新诊断的局限性前列腺癌，他无症状就诊。常规mNGS筛查意外发现 ，提示恶性肿瘤可能促成有利于潜伏性结核再激活的免疫状态。该病例强调了mNGS作为高危人群隐匿性感染的快速、灵敏诊断辅助手段的作用。
