Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China.
Department of Rheumatology, the Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310009, PR China.
Sci Total Environ. 2024 Mar 10;915:170031. doi: 10.1016/j.scitotenv.2024.170031. Epub 2024 Jan 14.
Exposure to endocrine-disrupting chemicals (EDCs) has been linked to various immune deficiency disorders, including autoimmune diseases like Sjögren Syndrome (SjS). However, the detrimental effects of exposure to EDCs, including bisphenols, parabens, and triclosan (TCS), on SjS have been inadequately documented. Thus, we conducted a cross-sectional study that included both healthy individuals (controls) and patients with SjS (cases). We assessed serum concentrations of bisphenol A (BPA), bisphenol S (BPS), methyl parabens (MeP), ethyl parabens (EtP), and TCS. The relationship between the five EDCs levels and the risk of SjS was also explored. Additionally, we conducted an in-depth analysis of the collective influence of these EDCs mixtures on SjS, employing a weighted quantile sum regression model. Out of the five EDCs analyzed, EtP displayed the highest mean concentration (2.80 ng/mL), followed by BPA (2.66 ng/mL) and MeP (1.99 ng/mL), with TCS registering the lowest level (0.36 ng/mL). Notably, BPS exposure was significantly positively associated with the risk of being diagnosed with SjS (with an odds ratio [OR] of 1.17, p = 0.042). No statistically significant associations with SjS were observed for BPA, MeP, EtP, and TCS (p > 0.05). And we did not observe any significant effects of the EDCs mixture on SjS. To the best of our knowledge, this study is the first to suggest that BPS may potentially increase the risk of SjS. Although no significant effects were observed between other EDCs and SjS risk, we cannot disregard the potential harm of EDCs due to their non-monotonic dose response.
接触内分泌干扰化学物质（EDCs）与各种免疫缺陷疾病有关，包括自身免疫性疾病，如干燥综合征（SjS）。然而，EDCs 暴露，包括双酚 A（BPA）、对羟基苯甲酸酯、三氯生（TCS）等，对 SjS 的有害影响尚未得到充分记录。因此，我们进行了一项横断面研究，包括健康个体（对照组）和 SjS 患者（病例组）。我们评估了血清中双酚 A（BPA）、双酚 S（BPS）、甲基对羟基苯甲酸酯（MeP）、乙基对羟基苯甲酸酯（EtP）和 TCS 的浓度。还探讨了这五种 EDC 水平与 SjS 风险之间的关系。此外，我们还采用加权分位数总和回归模型对这些 EDC 混合物对 SjS 的综合影响进行了深入分析。在分析的五种 EDC 中，EtP 的平均浓度最高（2.80ng/mL），其次是 BPA（2.66ng/mL）和 MeP（1.99ng/mL），而 TCS 的浓度最低（0.36ng/mL）。值得注意的是，BPS 暴露与 SjS 诊断风险显著正相关（优势比 [OR]为 1.17，p=0.042）。BPA、MeP、EtP 和 TCS 与 SjS 无统计学显著相关性（p>0.05）。并且我们没有观察到 EDC 混合物对 SjS 有任何显著影响。据我们所知，这项研究首次表明 BPS 可能会增加 SjS 的风险。虽然其他 EDC 与 SjS 风险之间没有观察到显著影响，但我们不能忽视 EDC 由于其非单调剂量反应而可能带来的潜在危害。
