Lê Sylvie, Cecchin-Albertoni Chiara, Thomas Charlotte, Kemoun Philippe, Minty Matthieu, Blasco-Baque Vincent
Département Dentaire, Université Paul Sabatier III (UPS), 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, France.
Service d'Odontologie Toulouse, CHU Toulouse, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, France.
Diagnostics (Basel). 2023 Oct 12;13(20):3184. doi: 10.3390/diagnostics13203184.
Over the past decade, there have been significant advancements in the high-flow analysis of "omics," shedding light on the relationship between the microbiota and the host. However, the full recognition of this relationship and its implications in cardiometabolic diseases are still underway, despite advancements in understanding the pathophysiology of these conditions. Cardiometabolic diseases, which include a range of conditions from insulin resistance to cardiovascular disease and type 2 diabetes, continue to be the leading cause of mortality worldwide, with a persistently high morbidity rate. While the link between the intestinal microbiota and cardiometabolic risks has been extensively explored, the role of the oral microbiota, the second-largest microbiota in the human body, and specifically the dysbiosis of this microbiota in causing these complications, remains incompletely defined. This review aims to examine the association between the oral microbiota and cardiometabolic diseases, focusing on the dysbiosis of the oral microbiota, particularly in periodontal disease. Additionally, we will dive into the mechanistic aspects of this dysbiosis that contribute to the development of these complications. Finally, we will discuss potential prevention and treatment strategies, including the use of prebiotics, probiotics, and other interventions.
在过去十年中，“组学”的高通量分析取得了重大进展，揭示了微生物群与宿主之间的关系。然而，尽管在理解这些疾病的病理生理学方面取得了进展，但对这种关系及其在心脏代谢疾病中的影响的全面认识仍在进行中。心脏代谢疾病包括从胰岛素抵抗到心血管疾病和2型糖尿病等一系列病症，仍然是全球范围内的主要死亡原因，发病率持续居高不下。虽然肠道微生物群与心脏代谢风险之间的联系已得到广泛研究，但口腔微生物群（人体第二大微生物群）的作用，特别是这种微生物群的失调在导致这些并发症方面的作用，仍未完全明确。本综述旨在探讨口腔微生物群与心脏代谢疾病之间的关联，重点关注口腔微生物群的失调，尤其是在牙周病中的失调。此外，我们将深入探讨这种失调导致这些并发症发生的机制方面。最后，我们将讨论潜在的预防和治疗策略，包括使用益生元、益生菌和其他干预措施。
