Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.
China National Botanical Garden, Beijing 100093, China.
Molecules. 2023 Jan 6;28(2):586. doi: 10.3390/molecules28020586.
Nowadays, the demand for rosemary essential oils (REOs) in the cosmetic, food, and pharmaceutical industries is increasing, and the abundant germplasm resources of rosemary provide more possibilities for functional applications. The REOs from six cultivars were selected to evaluate and compare their bioactivities. REOs have good cellular antioxidant activity in scavenging reactive oxygen species, and the technology for order preference by similarity to an ideal solution (TOPSIS)-random forest multivariate model indicated that 'Dutch Mill' REO has the best antioxidant activity, which is closely related to its verbenone content. In addition, α-pinene-dominant REOs are more toxic to human keratinocytes, which is closely related to the content of α-pinene, as revealed by multivariate analyses. Moreover, anti-proliferative assays on six cancer cell lines showed that all REOs have a higher anti-proliferative ability against human pancreatic cancer cell line SW1990 and gastric epithelial cell line NCI-N87. Among them, 'Miss Jessopp's Upright' and 'Blue Lagoon' REOs exhibit more prominent anti-proliferative activity. Our study provides a reference value for exploring the application potential of different REOs by evaluating their differences in chemical composition and bioactivity.
如今，迷迭香精油（REOs）在化妆品、食品和制药行业的需求不断增加，迷迭香丰富的种质资源为其功能应用提供了更多的可能性。本研究选择了 6 个品种的 REOs 进行评价和比较其生物活性。REOs 具有良好的细胞抗氧化活性，可清除活性氧，通过理想解排序法-随机森林多元模型（TOPSIS）分析表明，“荷兰磨坊”REO 具有最佳的抗氧化活性，这与其马鞭草酮含量密切相关。此外，多元分析表明，α-蒎烯含量较高的 REOs 对人角质形成细胞的毒性更大。此外，对 6 种癌细胞系的抗增殖实验表明，所有 REOs 对人胰腺癌细胞系 SW1990 和胃上皮细胞系 NCI-N87 均具有更高的抗增殖能力。其中，“Miss Jessopp's Upright”和“Blue Lagoon”REOs 表现出更显著的抗增殖活性。本研究通过评价不同 REOs 在化学成分和生物活性方面的差异，为探索其应用潜力提供了参考价值。
