Department of Pharmacology, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himachal Pradesh, India.
School of Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan 173229, Himachal Pradesh, India.
Molecules. 2023 Jan 11;28(2):750. doi: 10.3390/molecules28020750.
Due to genetic changes in DNA (deoxyribonucleic acid) sequences, cancer continues to be the second most prevalent cause of death. The traditional target-directed approach, which is confronted with the importance of target function in healthy cells, is one of the most significant challenges in anticancer research. Another problem with cancer cells is that they experience various mutations, changes in gene duplication, and chromosomal abnormalities, all of which have a direct influence on the potency of anticancer drugs at different developmental stages. All of these factors combine to make cancer medication development difficult, with low clinical licensure success rates when compared to other therapy categories. The current review focuses on the pathophysiology and molecular aspects of common cancer types. Currently, the available chemotherapeutic drugs, also known as combination chemotherapy, are associated with numerous adverse effects, resulting in the search for herbal-based alternatives that attenuate resistance due to cancer therapy and exert chemo-protective actions. To provide new insights, this review updated the list of key compounds that may enhance the efficacy of cancer treatment.
由于 DNA（脱氧核糖核酸）序列的遗传变化，癌症仍然是第二大致死原因。传统的靶向药物治疗方法面临着目标在健康细胞中功能的重要性，这是抗癌研究中最重大的挑战之一。癌细胞的另一个问题是它们经历各种突变、基因复制的变化和染色体异常，所有这些都直接影响不同发育阶段抗癌药物的效力。所有这些因素加在一起，使得癌症药物开发变得困难，与其他治疗类别相比，临床许可成功率较低。本综述重点介绍常见癌症类型的病理生理学和分子方面。目前，可用的化疗药物，也称为联合化疗，与许多不良反应相关，导致人们寻找基于草药的替代品，以减轻因癌症治疗而产生的耐药性，并发挥化疗保护作用。为了提供新的见解，本综述更新了可能提高癌症治疗效果的关键化合物列表。
