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从土壤中分离得到的链霉菌 NBERC-24992 中的苯并杂环化合物的抗病毒活性。

Antiviral Activity of Benzoheterocyclic Compounds from Soil-Derived Streptomyces jiujiangensis NBERC-24992.

机构信息

Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan 430064, China.

Institute of Infection, Immunology and Tumor Microenvironment, Institute of Pharmaceutical Process, Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, No. 2, Huangjiahu East Road, Hongshan District, Wuhan 430081, China.

出版信息

Molecules. 2023 Jan 15;28(2):878. doi: 10.3390/molecules28020878.

DOI:10.3390/molecules28020878
PMID:36677936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9866866/
Abstract

Pseudorabies virus (PRV) is a pathogen that causes Aujeszky's disease (AD) in animals, leading to huge economic losses to swine farms. In order to discover anti-PRV compounds, we studied the extracts of the strain NBERC-24992, which showed significant anti-PRV activity. Eight benzoheterocyclic secondary metabolites, including three new compounds (-, virantmycins D-G) and five known compounds (-, virantmycin, A-503451 D, A-503451 D acetylate, A-503451 A, and A-503451 B), were isolated from the broth of NBERC-24992. The structures of the new compounds were identified by using extensive spectroscopic data, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compound was found to be a novel heterocyclic compound with a tricyclic skeleton from natural product. All compounds were tested for antiviral activity, and (virantmycin) showed an excellent effect against PRV and was better than ribavirin and acyclovir. Our study revealed that chlorine atom and tetrahydroquinoline skeleton were important active moiety for antiviral activity. Virantmycin could be a suitable leading compound for an antiviral drug against PRV.

摘要

伪狂犬病毒（PRV）是一种病原体，可导致动物发生伪狂犬病（AD），给养猪场造成巨大的经济损失。为了发现抗 PRV 化合物，我们研究了表现出显著抗 PRV 活性的 NBERC-24992 株的提取物。从 NBERC-24992 的发酵液中分离出了 8 种苯并杂环类次生物质，包括 3 种新化合物（-, virantmycins D-G）和 5 种已知化合物（-, virantmycin, A-503451 D, A-503451 D 乙酰化，A-503451 A 和 A-503451 B）。新化合物的结构通过广泛的光谱数据（包括质谱（MS）、核磁共振（NMR）和电子圆二色性（ECD））确定。化合物 是一种从天然产物中发现的具有三环骨架的新型杂环化合物。所有化合物均进行了抗病毒活性测试，结果表明 （virantmycin）对 PRV 具有极好的抑制效果，优于利巴韦林和阿昔洛韦。我们的研究表明，氯原子和四氢喹啉骨架是抗病毒活性的重要活性部分。Virantmycin 可能是一种针对 PRV 的抗病毒药物的合适先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/2a7cb8bbd2d3/molecules-28-00878-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/1e75c75b0b98/molecules-28-00878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/0de049feaced/molecules-28-00878-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/f3126d9048c1/molecules-28-00878-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/2766705bb607/molecules-28-00878-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/9db46f450277/molecules-28-00878-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/e5ca260bf539/molecules-28-00878-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/343ffbbc7203/molecules-28-00878-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/2a7cb8bbd2d3/molecules-28-00878-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/1e75c75b0b98/molecules-28-00878-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/0de049feaced/molecules-28-00878-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/f3126d9048c1/molecules-28-00878-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/2766705bb607/molecules-28-00878-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/9db46f450277/molecules-28-00878-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/e5ca260bf539/molecules-28-00878-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/343ffbbc7203/molecules-28-00878-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6810/9866866/2a7cb8bbd2d3/molecules-28-00878-g008.jpg

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2
Actinobacteria in natural products research: Progress and prospects.天然产物研究中的放线菌：进展与展望。
Microbiol Res. 2021 May;246:126708. doi: 10.1016/j.micres.2021.126708. Epub 2021 Jan 22.
3
A Novel Human Acute Encephalitis Caused by Pseudorabies Virus Variant Strain.
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4
Bioactive Metabolites from Terrestrial and Marine Actinomycetes.陆地和海洋放线菌中的生物活性代谢产物。
Molecules. 2023 Aug 6;28(15):5915. doi: 10.3390/molecules28155915.
一种新型人疱疹病毒变异株引起的急性脑炎。
Clin Infect Dis. 2021 Dec 6;73(11):e3690-e3700. doi: 10.1093/cid/ciaa987.
4
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5
Pseudorabies virus encephalitis in humans: a case series study.人类伪狂犬病脑炎：病例系列研究。
J Neurovirol. 2020 Aug;26(4):556-564. doi: 10.1007/s13365-020-00855-y. Epub 2020 Jun 22.
6
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