Huan Changchao, Xu Yao, Zhang Wei, Ni Bo, Gao Song
Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
Viruses. 2022 Aug 14;14(8):1772. doi: 10.3390/v14081772.
Pseudorabies virus (PRV) is one of the most important pathogens causing serious diseases and leads to huge economic losses in the global swine industry. With the continuous emergence of PRV variants and the increasing number of cases of human infection, there is an urgent need to develop antiviral drugs. In this study, we discover that Glycyrrhiza polysaccharide (GCP) has anti-PRV infection activity in vitro, and 600 μg/mL GCP can completely block viral infection. The addition of GCP simultaneously with or after PRV infection had a significant inhibitory effect on PRV. Addition of GCP at different times of the virus life cycle mainly led to the inhibition of the attachment and internalization of PRV but does not affect viral replication and release. Our findings suggest that GCP has potential as a drug against PRV infection.
伪狂犬病病毒（PRV）是导致严重疾病的最重要病原体之一，在全球养猪业中造成巨大经济损失。随着PRV变异株的不断出现以及人类感染病例的增加，迫切需要开发抗病毒药物。在本研究中，我们发现甘草多糖（GCP）在体外具有抗PRV感染活性，600μg/mL的GCP可完全阻断病毒感染。在PRV感染的同时或之后添加GCP对PRV具有显著的抑制作用。在病毒生命周期的不同时间添加GCP主要导致PRV的附着和内化受到抑制，但不影响病毒的复制和释放。我们的研究结果表明，GCP具有作为抗PRV感染药物的潜力。
