Department of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Nutrients. 2023 Jan 14;15(2):440. doi: 10.3390/nu15020440.
The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B1, B6, and B12 levels were significantly lower in the HD group than in the control group (p < 0.001). Vitamin B1 and B2 were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; p < 0.05). Vitamin B3, B12, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; p < 0.05). Among diabetic patients, only the concentration of vitamin B1 was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.
水溶性维生素（叶酸和维生素 B12 除外）的浓度通常不会被测量，这可能导致血液透析（HD）患者出现未确诊的缺乏症。本研究的目的是评估 HD 患者血液中水溶性维生素的浓度，并与健康受试者进行比较，同时评估糖尿病（DM）共存对这些维生素浓度的影响。这项双中心研究纳入了 142 名 HD 患者和 31 名健康对照组。采用高效液相色谱法（HPLC）测定维生素浓度。HD 组的维生素 B1、B6 和 B12 水平明显低于对照组（p<0.001）。维生素 B1 和 B2 与 HD 前的血尿素氮（BUN）水平呈负相关（R = -0.39，R = -0.38；p<0.05）。维生素 B3、B12 和 C 与白蛋白浓度呈正相关（R = 0.26，R = 0.27，R = 0.28；p<0.05）。在糖尿病患者中，只有维生素 B1 的浓度低于非糖尿病患者。水溶性维生素的浓度可能与透析充分性、上次透析后实验室测定时间、饮食、其他疾病共存、个体患者用药和膳食补充剂有关。
