Chu K C
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892.
J Chronic Dis. 1987;40 Suppl 2:163S-170S. doi: 10.1016/s0021-9681(87)80019-x.
A qualitative view of mathematical models for cancer is presented. The Armitage and Doll multistage and Moolgavkar two-stage models of cancer are discussed in terms of their physical models. Time-related factors for these models as well as some of their characteristics are presented. The effect of age at first exposure, duration of exposure, time since last exposure and stage of carcinogenic effect on risk are detailed.
本文提出了对癌症数学模型的定性观点。从其物理模型的角度讨论了阿米蒂奇和多尔的多阶段癌症模型以及穆尔加夫卡尔的两阶段癌症模型。介绍了这些模型的时间相关因素及其一些特征。详细阐述了首次暴露年龄、暴露持续时间、上次暴露以来的时间以及致癌效应阶段对风险的影响。
