基于聚多巴胺/硫酸软骨素/聚乙烯醇复合水凝胶的多孔支架
Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels.
作者信息
Tang Zuwu, Yu Meiqiong, Mondal Ajoy Kanti, Lin Xinxing
机构信息
School of Materials and Environmental Engineering, Fujian Polytechnic Normal University, No.1, Campus New Village, Longjiang Street, Fuzhou 350300, China.
College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350108, China.
出版信息
Polymers (Basel). 2023 Jan 5;15(2):271. doi: 10.3390/polym15020271.
In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering.
在本文中，通过冷冻/解冻法，使用聚多巴胺（PDA）、硫酸软骨素（CS）和聚乙烯醇（PVA）制备了基于复合水凝胶的多孔支架。研究了所制备复合水凝胶的不同特性，包括孔径、抗压强度、搭接剪切强度、质量损失和细胞相容性。扫描电子显微镜图像（SEM）显示水凝胶孔径范围为20至100μm。复合水凝胶表现出95.1%的优异孔隙率、5.2MPa的抗压强度、在猪皮肤上21kPa的搭接剪切强度以及16.0%的质量损失。此外，复合水凝胶具有97%的良好相对细胞活性。以PDA/CS/PVA水凝胶具有细胞相容性为起点，它可在组织工程中作进一步研究。
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