Jiang Enhui, Wang Hongyang, Li Xuelan, Bi Yi, Mao Cui, Jiang Fugui, Song Enliang, Lan Xianyong
Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Institute of Animal Science and Veterinary, Shandong Academy of Agriculture Science, Jinan, Shandong, China.
Anim Biotechnol. 2023 Dec;34(9):4553-4558. doi: 10.1080/10495398.2023.2166841. Epub 2023 Jan 22.
() gene is well-known for its function in plateau hypoxia adaptability. It encodes HIF-2α, which involved in the induction of genes regulated by oxygen and then affects multiple physiological processes such as angiogenesis and energy metabolism. All of these indicate it may affect the development of animals. In this study, a 14-bp deletion in gene was uncovered in Shandong black cattle population ( = 502). Two genotypes (II and ID) were found and the frequency of the homozygous II genotype is higher than the heterozygous ID genotype. This population is consisted with HWE ( > 0.05). And more importantly, the 14-bp deletion was associated with outside flat ( = 0.003), brisket ( = 0.001), and knuckle ( = 0.032). These findings suggested that the 14-bp deletion is significantly associated with carcass traits, which could be served as a molecular marker applied to cow breeding.
（）基因因其在高原缺氧适应性中的功能而闻名。它编码缺氧诱导因子-2α（HIF-2α），HIF-2α参与诱导受氧气调节的基因，进而影响血管生成和能量代谢等多个生理过程。所有这些表明它可能影响动物的发育。在本研究中，在山东黑牛群体（n = 502）中发现了该基因的一个14bp缺失。发现了两种基因型（II和ID），纯合II基因型的频率高于杂合ID基因型。该群体符合哈迪-温伯格平衡（P>0.05）。更重要的是，14bp缺失与外部扁平度（P = 0.003）、胸肉（P = 0.001）和膝关节（P = 0.032）相关。这些发现表明，14bp缺失与胴体性状显著相关，可作为分子标记应用于奶牛育种。
