Department of Endocrinology and Metabolism, University Hospitals of Edinburgh, Edinburgh EH4 2XU, United Kingdom.
Department of Endocrinology and Metabolism, Lancashire Teaching Hospitals NHS Trust, Preston PR2 9HT, United Kingdom.
World J Gastroenterol. 2023 Jan 7;29(1):126-143. doi: 10.3748/wjg.v29.i1.126.
The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists. Management of these individual disorders in a patient should be addressed wholistically using an appropriate multidisciplinary team approach involving both the specialists and, when necessary, liaising with dieticians and surgeons. This comprehensive review is to compile the current evidence from a diabetologist's perspective on MAFLD and T2DM and to suggest optimal management strategies.
代谢综合征是肥胖流行的结果,导致代谢相关脂肪性肝病(MAFLD)和 2 型糖尿病(T2DM)的患病率显著增加。由于 T2DM 和 MAFLD 之间存在相似的病理生物学特征,这两种疾病在许多患者中同时存在,并且可能会相互影响,导致疾病相关结局的快速进展和个体疾病并发症的增加。事实上,肝科医生和内分泌科医生往往忽略了这种共存和并发症的风险。在治疗这些患者时,应该采用适当的多学科团队方法,由专家团队整体处理,必要时与营养师和外科医生联系。本综述旨在从内分泌科医生的角度综合整理 MAFLD 和 T2DM 的现有证据,并提出最佳的管理策略。