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间充质基质/干细胞衍生的外泌体与泌尿生殖系统癌症:一篇综述

Mesenchymal stromal/stem cell-derived exosomes and genitourinary cancers: A mini review.

作者信息

Salehpour Aria, Balmagambetova Saule, Mussin Nadiar, Kaliyev Asset, Rahmanifar Farhad

机构信息

PerciaVista R&D Co.Ltd, Shiraz, Iran.

Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

出版信息

Front Cell Dev Biol. 2023 Jan 4;10:1115786. doi: 10.3389/fcell.2022.1115786. eCollection 2022.

Abstract

Mesenchymal stromal/stem cell- (MSC-) derived exosomes are gaining popularity for their involvement in tissue repair and repressing various tumors through extensive patterns. Nevertheless, the impact of extracellular vesicles produced by stem cells on tumor formation and progression is controversial and seems to depend on several factors. The utilization of MSCs' various capabilities in urogenital neoplasms is widely regarded as a potential future therapeutic as well. These genitourinary neoplasms include prostatic neoplasms, ovarian neoplasms, cervical neoplasms, endometrial neoplasms, bladder neoplasms, and renal cell neoplasms. The present study has concentrated on the most recent information on genitourinary neoplasms employing MSCs derived exosomes' many capabilities, such as delivering effective RNAs, extensive tissue compatibility, and specificity with tumor identification without inherent limitations of cell therapy.

摘要

间充质基质/干细胞(MSC)衍生的外泌体因其参与组织修复以及通过多种方式抑制各种肿瘤而越来越受到关注。然而,干细胞产生的细胞外囊泡对肿瘤形成和进展的影响存在争议,似乎取决于几个因素。间充质干细胞的各种能力在泌尿生殖系统肿瘤中的应用也被广泛认为是未来一种潜在的治疗方法。这些泌尿生殖系统肿瘤包括前列腺肿瘤、卵巢肿瘤、宫颈肿瘤、子宫内膜肿瘤、膀胱肿瘤和肾细胞肿瘤。本研究集中于利用间充质干细胞衍生外泌体的多种能力,如传递有效RNA、广泛的组织相容性以及肿瘤识别特异性等方面的最新信息,且不存在细胞治疗的固有局限性,以研究泌尿生殖系统肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cba/9845763/afc885b1463c/fcell-10-1115786-g001.jpg

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