Huerne Katherine, Filion Kristian B, Grad Roland, Ernst Pierre, Gershon Andrea S, Eisenberg Mark J
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Department of Medicine, Division of Experimental Medicine, and Biomedical Ethics Unit, McGill University, Montreal, QC, Canada.
Am J Med Open. 2023 Jun;9:100033. doi: 10.1016/j.ajmo.2023.100033. Epub 2023 Jan 18.
Long COVID, or post-acute COVID-19 syndrome, is characterized by multi-organ symptoms lasting 2+ months after initial COVID-19 virus infection. This review presents the current state of evidence for long COVID syndrome, including the global public health context, incidence, prevalence, cardiopulmonary sequelae, physical and mental symptoms, recovery time, prognosis, risk factors, rehospitalization rates, and the impact of vaccination on long COVID outcomes. Results are presented by clinically relevant subgroups. Overall, 10-35% of COVID survivors develop long COVID, with common symptoms including fatigue, dyspnea, chest pain, cough, depression, anxiety, post-traumatic stress disorder, memory loss, and difficulty concentrating. Delineating these issues will be crucial to inform appropriate post-pandemic health policy and protect the health of COVID-19 survivors, including potentially vulnerable or underrepresented groups. Directed to policymakers, health practitioners, and the general public, we provide recommendations and suggest avenues for future research with the larger goal of reducing harms associated with long COVID syndrome.
长期新冠，即新冠后急性综合征，其特征是在初次感染新冠病毒后，多器官症状持续两个月以上。本综述介绍了长期新冠综合征的现有证据状况，包括全球公共卫生背景、发病率、患病率、心肺后遗症、身心症状、恢复时间、预后、风险因素、再住院率以及疫苗接种对长期新冠结局的影响。结果按临床相关亚组呈现。总体而言，10%至35%的新冠康复者会出现长期新冠症状，常见症状包括疲劳、呼吸困难、胸痛、咳嗽、抑郁、焦虑、创伤后应激障碍、记忆力减退和注意力不集中。明确这些问题对于制定适当的疫情后卫生政策以及保护新冠康复者的健康至关重要，包括潜在的弱势群体或代表性不足的群体。针对政策制定者、卫生从业者和公众，我们提供了建议，并提出了未来研究的方向，其更大目标是减少与长期新冠综合征相关的危害。
