Kurup Aswathy Rajendra, Wigdahl Jeff, Benson Jeremy, Martínez-Ramón Manel, Solíz Peter, Joshi Vinayak
Department of Electrical Engineering, The University of New Mexico, NM, USA.
VisionQuest Biomedical Inc., Albuquerque, NM, USA.
Biocybern Biomed Eng. 2023 Jan-Mar;43(1):109-123. doi: 10.1016/j.bbe.2022.12.003. Epub 2022 Dec 21.
Cerebral malaria (CM) is a fatal syndrome found commonly in children less than 5 years old in Sub-saharan Africa and Asia. The retinal signs associated with CM are known as malarial retinopathy (MR), and they include highly specific retinal lesions such as whitening and hemorrhages. Detecting these lesions allows the detection of CM with high specificity. Up to 23% of CM, patients are over-diagnosed due to the presence of clinical symptoms also related to pneumonia, meningitis, or others. Therefore, patients go untreated for these pathologies, resulting in death or neurological disability. It is essential to have a low-cost and high-specificity diagnostic technique for CM detection, for which We developed a method based on transfer learning (TL). Models pre-trained with TL select the good quality retinal images, which are fed into another TL model to detect CM. This approach shows a 96% specificity with low-cost retinal cameras.
脑型疟疾(CM)是一种常见于撒哈拉以南非洲和亚洲5岁以下儿童的致命综合征。与CM相关的视网膜体征被称为疟疾视网膜病变(MR),包括高度特异性的视网膜病变,如白化和出血。检测这些病变可实现对CM的高特异性检测。高达23%的CM患者因同时存在与肺炎、脑膜炎或其他疾病相关的临床症状而被过度诊断。因此,这些患者的这些病症得不到治疗,导致死亡或神经残疾。拥有一种低成本、高特异性的CM检测诊断技术至关重要,为此我们开发了一种基于迁移学习(TL)的方法。用TL预训练的模型选择高质量的视网膜图像,将其输入另一个TL模型以检测CM。这种方法使用低成本视网膜相机显示出96%的特异性。