一种基于残差图卷积网络的胃癌亚型分类方法。
A classification method of gastric cancer subtype based on residual graph convolution network.
作者信息
Liu Can, Duan Yuchen, Zhou Qingqing, Wang Yongkang, Gao Yong, Kan Hongxing, Hu Jili
机构信息
School of Medical Informatics Engineering, Anhui University of Chinese Medicine, Hefei, Anhui, China.
Anhui Computer Application Research Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Hefei, Anhui, China.
出版信息
Front Genet. 2023 Jan 4;13:1090394. doi: 10.3389/fgene.2022.1090394. eCollection 2022.
Clinical diagnosis and treatment of tumors are greatly complicated by their heterogeneity, and the subtype classification of cancer frequently plays a significant role in the subsequent treatment of tumors. Presently, the majority of studies rely far too heavily on gene expression data, omitting the enormous power of multi-omics fusion data and the potential for patient similarities. In this study, we created a gastric cancer subtype classification model called RRGCN based on residual graph convolutional network (GCN) using multi-omics fusion data and patient similarity network. Given the multi-omics data's high dimensionality, we built an artificial neural network Autoencoder (AE) to reduce the dimensionality of the data and extract hidden layer features. The model is then built using the feature data. In addition, we computed the correlation between patients using the Pearson correlation coefficient, and this relationship between patients forms the edge of the graph structure. Four graph convolutional network layers and two residual networks with skip connections make up RRGCN, which reduces the amount of information lost during transmission between layers and prevents model degradation. The results show that RRGCN significantly outperforms other classification methods with an accuracy as high as 0.87 when compared to four other traditional machine learning methods and deep learning models. In terms of subtype classification, RRGCN excels in all areas and has the potential to offer fresh perspectives on disease mechanisms and disease progression. It has the potential to be used for a broader range of disorders and to aid in clinical diagnosis.
肿瘤的异质性极大地增加了临床诊断和治疗的复杂性,而癌症的亚型分类在肿瘤的后续治疗中常常起着重要作用。目前,大多数研究过于依赖基因表达数据,而忽略了多组学融合数据的巨大力量以及患者相似性的潜力。在本研究中,我们使用多组学融合数据和患者相似性网络,基于残差图卷积网络(GCN)创建了一种名为RRGCN的胃癌亚型分类模型。鉴于多组学数据的高维度,我们构建了一个人工神经网络自动编码器(AE)来降低数据维度并提取隐藏层特征。然后使用特征数据构建模型。此外,我们使用皮尔逊相关系数计算患者之间的相关性,患者之间的这种关系构成了图结构的边。RRGCN由四个图卷积网络层和两个带有跳跃连接的残差网络组成,它减少了层间传输过程中丢失的信息量,防止模型退化。结果表明,与其他四种传统机器学习方法和深度学习模型相比,RRGCN的准确率高达(0.87),显著优于其他分类方法。在亚型分类方面,RRGCN在各个方面都表现出色,有潜力为疾病机制和疾病进展提供新的视角。它有潜力用于更广泛的疾病,并有助于临床诊断。