has potential to be a biomarker for cancer prognosis: A pan-cancer analysis.

INTRODUCTION

is a gene associated with the immune system and is thought to play a crucial role in autoimmunity. There are few -related studies in cancer, and it is assumed that is a proto-oncogene. There is currently no pan-cancer analysis of , and we performed a systematic and comprehensive pan-cancer analysis of in an attempt to reveal its role and function in cancer.

METHODS

The data were analyzed by mining databases available to the public and by using R software. Moreover, immunohistochemistry was used to validate the results.

RESULTS

Our results revealed that is commonly aberrantly expressed in cancer and its expression is strongly correlated with survival prognosis in a variety of cancer types. Through correlation analysis we found that was associated with multiple immune genes and was closely related to immune infiltration. In the enrichment analysis, may have cross-talk with multiple cancer pathways and exert oncogenic or pro-cancer functions. In addition, we collected pathological samples from colorectal cancer patients for immunohistochemical analysis and found that patients with higher immunohistochemical scores had more lymph node metastases, higher CA199, and bigger tumor size.

DISCUSSION

Overall, expression is closely related to cancers and has the potential to act as a cancer biomarker.