Yuan Ziming, Zhong Yuchen, Hu Hanqing, Zhang Weiyuan, Wang Guiyu
Cancer Center/Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Front Oncol. 2023 Jan 4;12:1064376. doi: 10.3389/fonc.2022.1064376. eCollection 2022.
is a gene associated with the immune system and is thought to play a crucial role in autoimmunity. There are few -related studies in cancer, and it is assumed that is a proto-oncogene. There is currently no pan-cancer analysis of , and we performed a systematic and comprehensive pan-cancer analysis of in an attempt to reveal its role and function in cancer.
The data were analyzed by mining databases available to the public and by using R software. Moreover, immunohistochemistry was used to validate the results.
Our results revealed that is commonly aberrantly expressed in cancer and its expression is strongly correlated with survival prognosis in a variety of cancer types. Through correlation analysis we found that was associated with multiple immune genes and was closely related to immune infiltration. In the enrichment analysis, may have cross-talk with multiple cancer pathways and exert oncogenic or pro-cancer functions. In addition, we collected pathological samples from colorectal cancer patients for immunohistochemical analysis and found that patients with higher immunohistochemical scores had more lymph node metastases, higher CA199, and bigger tumor size.
Overall, expression is closely related to cancers and has the potential to act as a cancer biomarker.
[基因名称]是一种与免疫系统相关的基因，被认为在自身免疫中起关键作用。在癌症方面，与该基因相关的研究较少，并且推测它是一种原癌基因。目前尚无关于该基因的泛癌分析，我们进行了一项系统全面的该基因泛癌分析，试图揭示其在癌症中的作用和功能。
通过挖掘公开可用的数据库并使用R软件对数据进行分析。此外，采用免疫组织化学方法验证结果。
我们的结果显示，该基因在癌症中普遍异常表达，其表达与多种癌症类型的生存预后密切相关。通过相关性分析，我们发现该基因与多个免疫基因相关，并且与免疫浸润密切相关。在富集分析中，该基因可能与多种癌症通路存在相互作用，并发挥致癌或促癌功能。此外，我们收集了结直肠癌患者的病理样本进行免疫组织化学分析，发现免疫组织化学评分较高的患者有更多的淋巴结转移、更高的CA199水平和更大的肿瘤尺寸。
总体而言，该基因的表达与癌症密切相关，并且有潜力作为一种癌症生物标志物。
