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拔牙后单独使用胶原细胞封闭膜以及联合脱矿骨基质保存剩余牙槽嵴的组织形态计量学分析：一项随机对照试验

Histomorphometric Analysis of Residual Alveolar Ridge Preserved using Collagen Cell Occlusive Membrane Alone and Along with Demineralized Bone Matrix Following Tooth Extraction: A Randomized Control Trial.

作者信息

Raj Subash Chandra, Pradhan Shiba Shankar, Mahapatra Annuroopa, Katti Neelima, Mohanty Devapratim, Rath Rachna, Patnaik Kaushik, Agrawal Poonam

机构信息

Department of Periodontics, S. C. B Dental College and Hospital, Cuttack, Odisha, India.

Department of Oral Pathology, S. C. B Dental College and Hospital, Cuttack, Odisha, India.

出版信息

Contemp Clin Dent. 2022 Oct-Dec;13(4):375-382. doi: 10.4103/ccd.ccd_347_21. Epub 2022 Nov 8.

DOI:10.4103/ccd.ccd_347_21
PMID:36686994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9855258/
Abstract

CONTEXT

The changes in the volume and dimensions of the alveolar bone after tooth extraction often lead to challenges in prosthetic rehabilitation of the same necessitating ridge preservation procedures (RPP).

AIM

The aim of this randomized clinical trial was to evaluate and compare the dimensional and histomorphometric changes of the sites preserved using the collagen membrane with and without demineralized bone matrix (DMBM).

SETTINGS AND DESIGN

Interventional, parallel-design, double blinded, randomized controlled trail.

MATERIALS AND METHODS

A randomized controlled trial was designed with 45 participants having at least 2 teeth indicated for were enrolled in this study. The sites were randomly assigned to the control group (RPP using collagen membrane) and the test group (RPP using collagen membrane with DMBM). The clinical parameters assessed were alveolar bone width and alveolar bone height. Histomorphometric analysis was carried out on tissue trephined from the preserved sites to evaluate the percentage of bone and connective tissue (CT %) formed 8 months postRPP.

STATISTICAL ANALYSIS USED

Shapiro - Wilk test and paired and unpaired -test.

RESULTS

Horizontal resorption was significantly less in the test group (7.375 ± 1.64). Histomorphometry of these sites revealed a complete absence of residual graft particles, presence of trabecular bone, and a more mineralized matrix (63.256%) as compared to the control sites (46.833%).

CONCLUSIONS

The use of DMBM along with the collagen membrane for RPP yielded better results both clinically and histomorphometically.

摘要

背景

拔牙后牙槽骨的体积和尺寸变化常常给义齿修复带来挑战，因此需要进行牙槽嵴保存术（RPP）。

目的

本随机临床试验旨在评估和比较使用胶原膜联合或不联合脱矿骨基质（DMBM）保存的位点的尺寸和组织形态计量学变化。

设置与设计

干预性、平行设计、双盲、随机对照试验。

材料与方法

设计一项随机对照试验，纳入45名至少有2颗牙需要拔除的参与者。这些位点被随机分配到对照组（使用胶原膜进行RPP）和试验组（使用胶原膜联合DMBM进行RPP）。评估的临床参数为牙槽骨宽度和牙槽骨高度。对从保存位点获取的组织环钻进行组织形态计量学分析，以评估RPP后8个月形成的骨和结缔组织的百分比（CT%）。

所用统计分析方法

Shapiro - Wilk检验以及配对和非配对检验。

结果

试验组的水平吸收明显较少（7.375±1.64）。这些位点的组织形态计量学显示完全没有残留的移植颗粒，存在小梁骨，并且与对照位点（46.833%）相比，基质矿化程度更高（63.256%）。

结论

在RPP中使用DMBM联合胶原膜在临床和组织形态计量学方面均产生了更好的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f3/9855258/56ddac0a8ffb/CCD-13-375-g014.jpg
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