Chernyshov Pavel V, Marron Servando E, Boffa Michael J, Pustišek Nives, Manolache Liana, Kakourou Talia, Cachia Monique, Svyatenko Tetiana, Koumaki Dimitra, Chernyshov Andrii V, Tomas-Aragones Lucia
Department of Dermatology and Venereology, National Medical University, Kiev, Ukraine.
Department of Dermatology, University Hospital Miguel Servet, Aragon Psychodermatology Research Group (GAI+PD), Zaragoza, Spain.
JAAD Int. 2022 Nov 25;10:61-67. doi: 10.1016/j.jdin.2022.11.009. eCollection 2023 Mar.
The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) questionnaire is the first dermatology-specific proxy health related QoL instrument for children from birth to 4 years. Score meaning bands and the sensitivity to successful therapeutic intervention are important to interpret the clinical meaning of an instrument.
The aim of the present study was to check the sensitivity to successful therapeutic intervention and establish score bands of the InToDermQoL questionnaire.
Parents or grandparents of 424 children with skin diseases from Spain, Malta, Croatia, Romania, Greece, and Ukraine filled in national language versions of the InToDermQoL questionnaire. Disease severity of children with atopic dermatitis was assessed by SCORAD (Scoring atopic dermatitis). Cohen's d was used to assess the responsiveness of the instrument.
The mean total InToDermQoL scores significantly decreased after treatment. Severity grading of the SCORAD scores gave stratification of the InToDermQoL severity grades based on 95% confidence intervals. Scores below a calculated minimal important difference of 2 corresponded to no effect on patient's health related QoL.
Score banding may be slightly different across patient population and study context.
All 3 age-specific versions of the InToDermQoL questionnaire showed sensitivity to treatment. Score bands for the InToDermQoL questionnaire have been established.
婴幼儿皮肤病生活质量（InToDermQoL）问卷是首个针对出生至4岁儿童的皮肤病专用代理健康相关生活质量工具。分数意义区间以及对成功治疗干预的敏感性对于解释一种工具的临床意义很重要。
本研究的目的是检验InToDermQoL问卷对成功治疗干预的敏感性并确定其分数区间。
来自西班牙、马耳他、克罗地亚、罗马尼亚、希腊和乌克兰的424名皮肤病患儿的父母或祖父母填写了本国语言版本的InToDermQoL问卷。通过SCORAD（特应性皮炎评分）评估特应性皮炎患儿的疾病严重程度。使用科恩d值来评估该工具的反应性。
治疗后InToDermQoL总得分均值显著下降。SCORAD评分的严重程度分级基于95%置信区间对InToDermQoL严重程度等级进行了分层。低于计算得出的最小重要差异2分的分数对应于对患者健康相关生活质量无影响。
分数区间在不同患者群体和研究背景下可能略有不同。
InToDermQoL问卷的所有3个特定年龄版本均显示出对治疗的敏感性。已确定InToDermQoL问卷的分数区间。
