Huang J D
Department of Pharmacology, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China.
J Pharm Sci. 1987 Jul;76(7):525-7. doi: 10.1002/jps.2600760707.
The pharmacokinetic response of theophylline following the oral administration of activated charcoal was investigated in rabbits. Rabbits were continuously infused with a theophylline solution at a rate of 2.12 mg/h. At the fourth hour of theophylline infusion, 20 g of activated charcoal was administered by intubation to the rabbit (n = 12). The concentration of theophylline in serum gradually decreased after the charcoal treatment. The magnitude of the change in theophylline concentration induced by charcoal varied among animals. By comparing the steady-state theophylline concentration in the control and treated animals, the total body clearance was found to increase from 94.4 +/- 7.5 to 210 +/- 27 mL/h/kg (mean +/- SE). The rate of change of theophylline concentration in serum following charcoal treatment was fitted with a simulation curve by assuming a stepwise increase in clearance immediately following the charcoal treatment. The results indicated that activated charcoal exerted its maximum effect in increasing theophylline clearance immediately after its administration.
在兔子身上研究了口服活性炭后茶碱的药代动力学反应。兔子以2.12毫克/小时的速率持续输注茶碱溶液。在茶碱输注的第四小时，通过插管给兔子（n = 12）给予20克活性炭。活性炭处理后血清中茶碱的浓度逐渐降低。活性炭引起的茶碱浓度变化幅度在动物之间有所不同。通过比较对照动物和处理动物的稳态茶碱浓度，发现总体清除率从94.4±7.5增加到210±27毫升/小时/千克（平均值±标准误）。通过假设活性炭处理后清除率立即逐步增加，将活性炭处理后血清中茶碱浓度的变化率与模拟曲线拟合。结果表明，活性炭在给药后立即发挥其增加茶碱清除率的最大作用。
