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Vitamin D receptor activation in microglia suppresses NOX2-mediated oxidative damage via PAT1 in vitro and in vivo.

作者信息

Wang Changshui, Gao Yahao, Chen Beibei, Jiang Pei

机构信息

Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.

Clinical Medical School, Jining Medical University, Jining, China.

出版信息

Clin Transl Med. 2023 Jan;13(1):e1187. doi: 10.1002/ctm2.1187.

DOI:10.1002/ctm2.1187
PMID:36688461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9869429/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/5104b08e6502/CTM2-13-e1187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/01379b194b1f/CTM2-13-e1187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/6256e430397a/CTM2-13-e1187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/976becd3c275/CTM2-13-e1187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/5104b08e6502/CTM2-13-e1187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/01379b194b1f/CTM2-13-e1187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/6256e430397a/CTM2-13-e1187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/976becd3c275/CTM2-13-e1187-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8a2/9869429/5104b08e6502/CTM2-13-e1187-g003.jpg

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本文引用的文献

1
Microglia: Immune and non-immune functions.小胶质细胞：免疫和非免疫功能。
Immunity. 2021 Oct 12;54(10):2194-2208. doi: 10.1016/j.immuni.2021.09.014.
2
Systemic LPS-induced microglial activation results in increased GABAergic tone: A mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice.系统脂多糖诱导的小胶质细胞激活导致 GABA 能张力增加：一种在小鼠内侧前额叶皮质中对抗神经炎症的保护机制。
Brain Behav Immun. 2022 Jan;99:53-69. doi: 10.1016/j.bbi.2021.09.017. Epub 2021 Sep 25.
3
Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity.
酒精使用障碍、神经退行性变、阿尔茨海默病和帕金森病：氧化应激、神经免疫反应与兴奋性毒性之间的相互作用
Front Cell Neurosci. 2020 Aug 31;14:282. doi: 10.3389/fncel.2020.00282. eCollection 2020.
4
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.姜黄素通过恢复氧化应激和激活 Nrf2 信号通路的变化来减轻慢性不可预测轻度应激诱导的大鼠抑郁样行为。
Oxid Med Cell Longev. 2020 Sep 17;2020:9268083. doi: 10.1155/2020/9268083. eCollection 2020.
5
Inhibition of LPS-induced Nox2 activation by VAS2870 protects alveolar epithelial cells through eliminating ROS and restoring tight junctions.VAS2870 通过消除 ROS 和恢复紧密连接抑制 LPS 诱导的 Nox2 激活，从而保护肺泡上皮细胞。
Biochem Biophys Res Commun. 2020 Apr 9;524(3):575-581. doi: 10.1016/j.bbrc.2020.01.134. Epub 2020 Feb 1.
6
Calcitriol alleviates global cerebral ischemia-induced cognitive impairment by reducing apoptosis regulated by VDR/ERK signaling pathway in rat hippocampus.骨化三醇通过降低 VDR/ERK 信号通路调节的细胞凋亡减轻大鼠海马区全脑缺血诱导的认知功能障碍。
Brain Res. 2019 Dec 1;1724:146430. doi: 10.1016/j.brainres.2019.146430. Epub 2019 Aug 31.
7
The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.肌球蛋白轻链相关蛋白 PAT1 促进人吞噬细胞中超氧阴离子的产生。
J Immunol. 2019 Mar 1;202(5):1549-1558. doi: 10.4049/jimmunol.1800610. Epub 2019 Jan 21.
8
NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?NADPH 氧化酶作为神经退行性疾病的药物靶点和生物标志物：有何证据？
Free Radic Biol Med. 2017 Nov;112:387-396. doi: 10.1016/j.freeradbiomed.2017.08.006. Epub 2017 Aug 12.
9
Neurochemical effects of chronic administration of calcitriol in rats.大鼠长期服用骨化三醇的神经化学效应。
Nutrients. 2014 Dec 22;6(12):6048-59. doi: 10.3390/nu6126048.
10
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.防治血管疾病中的氧化应激：NADPH 氧化酶作为治疗靶点。
Nat Rev Drug Discov. 2011 Jun;10(6):453-71. doi: 10.1038/nrd3403.