Although probiotics' main known effects are in the digestive system, over the last years several benefits that come from their topical use, have been investigated. Several studies have reported beneficial effects on different skin disorders, such as atopic dermatitis, acne, eczema, psoriasis, wound healing, skin aging and reactive skin. Their main action is assigned to the inhibition of skin colonization by pathogens. In this work, the growths of three probiotic strains were evaluated in the presence of abiotic factors similar to those found in skin, namely, UV radiation, temperature, pH, NaCl and fatty acids. showed increased growth under the pH of 6, but no differences in its growth were found for the various NaCl concentrations tested. increased the number of bacterial cells in 88.8% when grown in 10 mM NaCl concentration, while showed increased growth at 45 °C. All tested probiotic bacteria were able to grow under skin-like conditions. However, was the probiotic that showed the best results. The results obtained in this study indicate that the used probiotics may be beneficial in the treatment of skin diseases, since they are able to successfully thrive in skin-like conditions.