Gitay Mehnaz Nuruddin, Sohail Arisha, Arzoo Yasmeen, Shakir Muhammad Ali
Dr. Mehnaz Nuruddin Gitay, Ph.D. Assistant Professor, Department of Biochemistry, Dow University of Health Science, Karachi, Pakistan.
Dr. Arisha Sohail, M.B.B.S, Ph.D. Lecturer, Department of Biochemistry, Dow University of Health Science, Karachi, Pakistan.
Pak J Med Sci. 2023 Jan-Feb;39(1):188-191. doi: 10.12669/pjms.39.1.6265.
To investigate the role of serum lipids in the onset and progression of Diabetic Retinopathy (DR) in Type-II diabetes (T2DM) individuals.
This cross-sectional study was conducted at the National Institute of Diabetes and Endocrinology (NIDE), Dow University of Health Sciences (DUHS) from March to May 2019. After signing the informed consent, healthy controls (n=30), T2DM patients (diabetic n=30), proliferative (PDR n=30) and non-proliferative (NPDR n= 30) of age 18 to 65 years were selected by convenient sampling. Background information was gathered through interviews and the fundoscopy was done. Fasting five ml venous blood samples were collected and analysed for triglycerides (TGs), cholesterol, HDL, LDL, VLDL and the HbA1c using commercially available assays. The SPSS, version 24.0, was used for data analysis.
The HbA1c level was high in the diabetes, NPDR and PDR groups than control (p<0.05). The serum TGs and cholesterol were raised while the HDL was low in the diabetes group than in control (p<0.05). The cholesterol and LDL were high in the diabetes group compared to NPDR and PDR groups (p<0.05). The cholesterol and VLDL showed a positive moderately strong correlation with HbA1c in the PDR group (p<0.05).
The serum lipid levels vary with the HbA1c levels and greater degree of derangement is observed with increasing mean HbA1C independent of diabetic retinopathy. For this reason, strict control of HbA1c and serum lipid level by lifestyle and/or pharmacologic intervention is recommended in diabetes with or without retinopathy.
探讨血脂在2型糖尿病（T2DM）患者糖尿病视网膜病变（DR）发病及进展中的作用。
本横断面研究于2019年3月至5月在道健康科学大学国家糖尿病与内分泌研究所（NIDE）进行。签署知情同意书后，通过方便抽样选取年龄在18至65岁的健康对照者（n = 30）、T2DM患者（糖尿病组n = 30）、增殖性糖尿病视网膜病变患者（PDR组n = 30）和非增殖性糖尿病视网膜病变患者（NPDR组n = 30）。通过访谈收集背景信息并进行眼底检查。采集5毫升空腹静脉血样本，使用市售检测方法分析甘油三酯（TGs）、胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）和糖化血红蛋白（HbA1c）。使用SPSS 24.0版进行数据分析。
糖尿病组、NPDR组和PDR组的HbA1c水平高于对照组（p < 0.05）。糖尿病组的血清TGs和胆固醇升高，而HDL低于对照组（p < 0.05）。糖尿病组的胆固醇和LDL高于NPDR组和PDR组（p < 0.05）。PDR组中胆固醇和VLDL与HbA1c呈中度强正相关（p < 0.05）。
血清脂质水平随HbA1c水平变化，且无论是否患有糖尿病视网膜病变，随着平均HbA1c升高，紊乱程度加剧。因此，建议对有或无视网膜病变的糖尿病患者通过生活方式和/或药物干预严格控制HbA1c和血清脂质水平。
