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2022 年 10 月，西班牙养殖水貂中高致病性禽流感 A(H5N1)病毒感染。

Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks, Spain, October 2022.

机构信息

Laboratorio Central de Veterinaria (LCV), Ministry of Agriculture, Fisheries and Food, Algete, Madrid, Spain.

Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Legnaro, Italy.

出版信息

Euro Surveill. 2023 Jan;28(3). doi: 10.2807/1560-7917.ES.2023.28.3.2300001.

DOI:10.2807/1560-7917.ES.2023.28.3.2300001
PMID:36695488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9853945/
Abstract

In October 2022, an outbreak in Europe of highly pathogenic avian influenza (HPAI) A(H5N1) in intensively farmed minks occurred in northwest Spain. A single mink farm hosting more than 50,000 minks was involved. The identified viruses belong to clade 2.3.4.4b, which is responsible of the ongoing epizootic in Europe. An uncommon mutation (T271A) in the PB2 gene with potential public health implications was found. Our investigations indicate onward mink transmission of the virus may have occurred in the affected farm.

摘要

2022 年 10 月，西班牙西北部的一个密集养殖水貂养殖场爆发了高致病性禽流感（HPAI）A（H5N1）疫情。该疫情涉及一个拥有超过 5 万只水貂的单一养殖场。鉴定出的病毒属于 2.3.4.4b 分支，该分支负责欧洲正在发生的疫情。在 PB2 基因中发现了一个具有潜在公共卫生意义的不常见突变（T271A）。我们的调查表明，受感染的养殖场中可能发生了病毒向水貂的传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87b0/9853945/a2a2eec729f6/2300001-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87b0/9853945/514e8c898b1d/2300001-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87b0/9853945/a2a2eec729f6/2300001-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87b0/9853945/514e8c898b1d/2300001-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87b0/9853945/a2a2eec729f6/2300001-f2.jpg

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2
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3
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Revealing Reassortment in Influenza A Viruses with TreeSort.
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5
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9
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