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注射水凝胶包埋双功能 Au@Pt 核壳纳米粒子通过抗氧化和电整合调节梗死微环境并增强干细胞的治疗效果。

Injectable Hydrogels Encapsulating Dual-Functional Au@Pt Core-Shell Nanoparticles Regulate Infarcted Microenvironments and Enhance the Therapeutic Efficacy of Stem Cells through Antioxidant and Electrical Integration.

机构信息

Beijing Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China.

Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing, 100029, China.

出版信息

ACS Nano. 2023 Feb 14;17(3):2053-2066. doi: 10.1021/acsnano.2c07436. Epub 2023 Jan 25.

DOI:10.1021/acsnano.2c07436
PMID:36695873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9933615/
Abstract

Injectable functional biomaterials have made significant progress in cardiac regenerative. In addition, how to adjust the abominable infarction microenvironment and introduce therapeutic stem cells to improve the healing effect has become a hotspot. Herein, injectable stem cell vector is prepared by combining natural alginate hydrogel and Au@Pt nanoparticles (Au@Pt/Alg hydrogel) to encapsulate brown adipose stem cells (BASCs). Au@Pt nanoparticles with both antioxidative and conductive properties could effectively eliminate reactive oxygen species, enhance the frequency of action potential release of cardiomyocytes, and further reduce the inflammatory factors of macrophage . The Au@Pt/Alg hydrogel enhances the antioxidant, differentiation, and paracrine capability of BASCs. The effect of BASCs loaded Au@Pt/Alg hydrogel is evaluated in a rat myocardial infarction (MI) model. The antioxidant, anti-inflammatory, and heart electrical integration are showed in the MI model. More interestingly, Au@Pt/Alg hydrogel can effectively maintain the paracrine efficiency and pro-angiogenesis effects of BASCs in the infarcted area. This study led us to recognize the great value of Au@Pt/Alg hydrogels for their ability to actively regulate the microenvironment and carry stem cells for MI treatment.

摘要

可注射功能生物材料在心脏再生方面取得了重大进展。此外，如何调节恶劣的梗塞微环境并引入治疗性干细胞以提高治疗效果已成为热点。在此，通过将天然海藻酸钠水凝胶和 Au@Pt 纳米粒子（Au@Pt/Alg 水凝胶）结合起来制备可注射的干细胞载体，以封装棕色脂肪干细胞（BASCs）。具有抗氧化和导电性的 Au@Pt 纳米粒子可以有效清除活性氧，增强心肌细胞动作电位释放的频率，进一步减少巨噬细胞的炎症因子。Au@Pt/Alg 水凝胶增强了 BASCs 的抗氧化、分化和旁分泌能力。在大鼠心肌梗死（MI）模型中评估了负载 BASCs 的 Au@Pt/Alg 水凝胶的效果。在 MI 模型中显示了抗氧化、抗炎和心脏电整合的作用。更有趣的是，Au@Pt/Alg 水凝胶可以有效地维持 BASCs 在梗塞区域的旁分泌效率和促血管生成作用。这项研究使我们认识到 Au@Pt/Alg 水凝胶在主动调节微环境和携带干细胞治疗 MI 方面的巨大价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/f34b9a6e3a15/nn2c07436_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/dcb9e05d8433/nn2c07436_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/71a303dabbcf/nn2c07436_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/dc8d10ac00cd/nn2c07436_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/e4fab0dc2d5c/nn2c07436_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/df2af6d05755/nn2c07436_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/d177c4092917/nn2c07436_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/f34b9a6e3a15/nn2c07436_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/dcb9e05d8433/nn2c07436_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/71a303dabbcf/nn2c07436_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/dc8d10ac00cd/nn2c07436_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/e4fab0dc2d5c/nn2c07436_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/df2af6d05755/nn2c07436_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/d177c4092917/nn2c07436_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f9f/9933615/f34b9a6e3a15/nn2c07436_0007.jpg

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