Intensive Care Unit, Ambroise-Paré Hospital, Assistance Publique Hôpitaux Paris and Paris Saclay University, Boulogne Billancourt, France
Centre de recherche en épidémiologie et santé des populations, Inserm U1018, Paris Saclay University, France
Ann Biol Clin (Paris). 2022 Nov 1;80(6):521-525. doi: 10.1684/abc.2022.1765.
Point of care testing (POCT) tests are needed to assess severity and to help for triage in hospital and in prehospital settings. Before their use, the analytical performances of POCTs have to be compared with central laboratory reference methods. In this study, we describe the comparability of results obtained by either the Abbott i-STAT® System POCT handheld device or the blood gases analyzer of the central laboratory of our hospital.
Sample blood from 37 septic patients admitted to the intensive care unit (ICU) were assayed by Abbott i-STAT® System POCT and Radiometer ABL800 Flex® lab analyzer. Studied parameters were as follows: pH, pO2, pCO2, base excess (BE), HCO3- and lactate. Comparability was evaluated using Bland-Altman method. The clinical value for possible mismatch issued of values differences was also assessed.
Quite acceptable correlations in results of POCT and laboratory analyzer were observed with R² most of time above 0.85. Bland-Altman analysis showed a bias of 1.26% for Abbott i-STAT® System POCT vs laboratory.
Abbott i-STAT® System POCT handheld device is comparable to Radiometer ABL800 Flex® lab analyzer and concordant with laboratory analysis. Abbott i-STAT® System POCT handled device could be used in the prehospital settings in order to evaluate the severity of sepsis.
在医院和院前环境中，需要进行即时检测（POCT）以评估严重程度并帮助分诊。在使用之前，必须将 POCT 的分析性能与中心实验室参考方法进行比较。在这项研究中，我们描述了 Abbott i-STAT® System POCT 手持式设备或我们医院中心实验室血气分析仪获得的结果的可比性。
对入住重症监护病房（ICU）的 37 名败血症患者的样本血液进行了 Abbott i-STAT® System POCT 和 Radiometer ABL800 Flex® 实验室分析仪的检测。研究的参数如下：pH 值、pO2、pCO2、碱剩余（BE）、HCO3-和乳酸。使用 Bland-Altman 方法评估可比性。还评估了由于值差异可能导致不匹配的临床价值。
POCT 和实验室分析仪的结果之间存在相当可接受的相关性，R² 多数时间高于 0.85。Bland-Altman 分析显示 Abbott i-STAT® System POCT 与实验室相比的偏差为 1.26%。
Abbott i-STAT® System POCT 手持式设备与 Radiometer ABL800 Flex® 实验室分析仪具有可比性，与实验室分析一致。 Abbott i-STAT® System POCT 手持式设备可用于院前环境，以评估败血症的严重程度。
