Jawa Ali, Motara Feroza, Moolla Muhammed, Laher Abdullah E
Emergency Medicine, University of the Witwatersrand, Johannesburg, ZAF.
Cureus. 2020 Aug 21;12(8):e9932. doi: 10.7759/cureus.9932.
Point-of-care testing (POCT) plays an integral role in the management of acutely ill patients presenting to the emergency department (ED). Due to its rapid turnaround time, POCT has been shown to improve ED workflow, reduce unnecessary admissions and lessen the burden on ED staff. The aim of the study was to compare the accuracy, precision and linearity of the Nova Stat Profile Prime Plus (Nova Biomedical, Waltham, MA, USA) to the Radiometer ABL800 FLEX (Radiometer South Africa Pty Ltd, Gauteng) and the Abbott i-stat Chem8+ (Abbott, Princeton, NJ, USA) POCT analyzers.
A convenience sample of 150 discarded whole blood specimens was obtained and analyzed. Paired test measurements were conducted for method comparison. Accuracy was measured by pairing individual results from the Nova Stat Profile Prime Plus with either the Radiometer ABL800 FLEX or the Abbot i-stat Chem8+ analyzers by calculating the differences.
The with-in run percentage coefficient of variation (%CV) was below 2.4% for pH, carboxyhemoglobin (COHb), deoxyhemoglobin (HHb), total hemoglobin (tHb), total bilirubin (tBil), sodium (Na), potassium (K), chloride (Cl), ionized calcium (iCa), urea, glucose and lactate, and was below 5.1% for all other analytes. The day-to-day %CV was below 1.6% for pH, COHb, HHb, tHb, tBil, Na, K, Cl, iCa, urea, glucose and lactate, and below 6.10% for all other analytes. The correlation coefficient (r) was 0.351 and ranged from 0.897 to 0.998 for all analytes. The mean bias was minimal for all analytes.
There was a good correlation between the Nova Stat Profile Prime Plus and the Radiometer ABL800 FLEX/Abbott i-STAT Chem8+ POCT analyzers. The Stat Profile Prime Plus exhibited good precision both within-run and day-to-day.
即时检验（POCT）在急诊科（ED）急性病患者的管理中发挥着不可或缺的作用。由于其周转时间短，POCT已被证明可改善急诊科工作流程、减少不必要的住院并减轻急诊科工作人员的负担。本研究的目的是比较诺瓦Stat Profile Prime Plus（美国马萨诸塞州沃尔瑟姆市的诺瓦生物医学公司）与雷度ABL800 FLEX（南非豪登省雷度南非私人有限公司）以及雅培i-STAT Chem8+（美国新泽西州普林斯顿市的雅培公司）POCT分析仪的准确性、精密度和线性度。
获取150份废弃全血标本的便利样本并进行分析。进行配对测试测量以进行方法比较。通过计算差异，将诺瓦Stat Profile Prime Plus的单个结果与雷度ABL800 FLEX或雅培i-STAT Chem8+分析仪的结果配对来测量准确性。
pH、碳氧血红蛋白（COHb）、脱氧血红蛋白（HHb）、总血红蛋白（tHb）、总胆红素（tBil）、钠（Na）、钾（K）、氯（Cl）、离子钙（iCa）、尿素、葡萄糖和乳酸的批内变异系数百分比（%CV）低于2.4%，所有其他分析物的批内变异系数百分比低于5.1%。pH、COHb、HHb、tHb、tBil、Na、K、Cl、iCa、尿素、葡萄糖和乳酸的日间%CV低于1.6%，所有其他分析物的日间%CV低于6.10%。所有分析物的相关系数（r）为0.351，范围为0.897至0.998。所有分析物的平均偏差最小。
诺瓦Stat Profile Prime Plus与雷度ABL800 FLEX/雅培i-STAT Chem8+ POCT分析仪之间存在良好的相关性。Stat Profile Prime Plus在批内和日间均表现出良好的精密度。
