Halperin J J, Little B W, Coyle P K, Dattwyler R J
Department of Neurology, State University of New York, Stony Brook 11794.
Neurology. 1987 Nov;37(11):1700-6. doi: 10.1212/wnl.37.11.1700.
Peripheral nerve dysfunction was demonstrated in 36% of patients with late Lyme disease. Of 36 patients evaluated, 14 had prominent limb paresthesias. Thirteen of these had neurophysiologic evidence of peripheral neuropathy; neurologic examinations were normal in most. Repeat testing following treatment documented rapid improvement in 11 of 12. We conclude that this neuropathy, which is quite different from the infrequent peripheral nerve syndromes previously described in this illness, is commonly present in late Lyme disease. This neuropathy presents with intermittent paresthesias without significant deficits on clinical examination and is reversible with appropriate antibiotic treatment. Neurophysiologic testing provides a useful diagnostic tool and an important measure of response to treatment.
36%的晚期莱姆病患者存在周围神经功能障碍。在接受评估的36例患者中，14例有明显的肢体感觉异常。其中13例有周围神经病变的神经生理学证据；大多数患者的神经系统检查正常。治疗后的重复检测表明，12例中有11例迅速改善。我们得出结论，这种神经病变与此前在该病中描述的罕见周围神经综合征截然不同，在晚期莱姆病中很常见。这种神经病变表现为间歇性感觉异常，临床检查无明显缺陷，经适当的抗生素治疗可逆转。神经生理学检测提供了一种有用的诊断工具，也是衡量治疗反应的重要指标。
