载姜黄素胶态纳米递药系统、技术及应用。

Bixin-loaded colloidal nanodelivery systems, techniques and applications.

机构信息

Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Food Chem. 2023 Jun 30;412:135479. doi: 10.1016/j.foodchem.2023.135479. Epub 2023 Jan 16.

DOI:10.1016/j.foodchem.2023.135479

PMID:36709686

Abstract

Bixin is the cis-carotenoid from the seed of achiote tree or annatto. It is an approved liposoluble apocarotenoid by FDA as colorant and additive in the food industry. Nonetheless, bixin is unstable in the presence of oxygen, light, high pHs (alkali) and heat; thereby reducing its bioavailability/bioactivity, and also, with a low solubility in water. Some biopolymeric (e.g., nanofibers, nanogels, and nanotubes) and lipid-based nanocarriers (nanoliposomes, niosomes, hexosomes, nanoemulsions, solid-lipid nanoparticles, and nanostructured lipid carriers) have been introduced for bixin. Thus, this review focuses on the updated information regarding bixin-loaded nanodelivery platforms. Moreover, it provides a comprehensive review of bioavailability, physicochemical properties, and applications of nanoencapsulated-bixin as an additive, its release rate and safety issues. These findings will bring potential strategies for the usage of nanocarriers in managing bixin defaults to improve its broad application in various industries.

摘要

胭脂树橙是胭脂树或红木种子中的顺式类胡萝卜素。它是 FDA 批准的脂溶性类胡萝卜素，可用作食品工业中的着色剂和添加剂。然而，胭脂树橙在氧气、光照、高 pH 值（碱性）和高温存在下不稳定；从而降低其生物利用度/生物活性，并且在水中的溶解度也较低。一些生物聚合物（例如，纳米纤维、纳米凝胶和纳米管）和基于脂质的纳米载体（脂质体纳米囊泡、非诺莫司、六方体、纳米乳液、固体脂质纳米粒和纳米结构脂质载体）已被用于负载胭脂树橙。因此，本综述重点介绍了有关负载胭脂树橙的纳米递药平台的最新信息。此外，它还全面综述了纳米封装胭脂树橙作为添加剂的生物利用度、物理化学性质和应用，以及其释放速率和安全问题。这些发现将为纳米载体在管理胭脂树橙缺陷以提高其在各个行业的广泛应用方面提供潜在策略。