Sohn Hyogon, Cooper Megan A
Division of Rheumatology/Immunology, Department of Pediatrics, Washington University, St. Louis, MO, USA.
Immunometabolism (Cobham). 2023 Jan 23;5(1):e00020. doi: 10.1097/IN9.0000000000000020. eCollection 2023 Jan.
Natural killer (NK) cells are innate immune lymphocytes capable of rapidly responding to tumors and infection without prior sensitization. There is increasing interest and success in harnessing NK cell function for the treatment of disease, in particular cancers. NK cell activation is dependent on integration of signals through cytokine and germline-encoded activating and inhibitory receptors. The availability of metabolic fuels and pathways is required for NK effector functions including proliferation, killing, and production of interferon gamma (IFN-γ). An understanding of NK cell immunometabolism is thus essential for developing immunotherapy approaches that will allow for optimal effector functions in patients. Studies in mice and humans have demonstrated stimulation-dependent metabolic changes that are required for NK cell function. Here we review the most recent findings in NK cell immunometabolism relevant to disease models and translation to therapy of patients.
自然杀伤（NK）细胞是先天性免疫淋巴细胞，能够在无需预先致敏的情况下快速对肿瘤和感染作出反应。利用NK细胞功能治疗疾病，尤其是癌症，正受到越来越多的关注并取得了越来越多的成功。NK细胞的激活依赖于通过细胞因子以及种系编码的激活和抑制性受体整合信号。包括增殖、杀伤和干扰素γ（IFN-γ）产生在内的NK效应功能需要代谢燃料和代谢途径的供应。因此，了解NK细胞免疫代谢对于开发能够使患者发挥最佳效应功能的免疫治疗方法至关重要。对小鼠和人类的研究已经证明了NK细胞功能所需的刺激依赖性代谢变化。在此，我们综述了与疾病模型以及向患者治疗转化相关的NK细胞免疫代谢的最新发现。
