Bradwell A R, Coote J H
Department of Immunology, Medical School, University of Birmingham, Edgbaston, UK.
Postgrad Med J. 1987 Mar;63(737):165-7. doi: 10.1136/pgmj.63.737.165.
Twenty-one subjects formed a trekking expedition to study the effects of acetazolamide on exercise performance and acclimatization at high altitude. Subjects were randomized to acetazolamide or placebo on a double blind basis. During ascent to and stay for 6 nights at 4846 m studies were carried out on blood gases, 2,3 diphosphoglycerate (2,3 DPG), proteinuria, exercise testing, intestinal absorption, purine metabolism and changes in body composition. The results showed beneficial effects of acetazolamide on exercise performance and preservation of muscle mass.
21名受试者组成了一支徒步探险队，以研究乙酰唑胺对高原运动表现和适应过程的影响。受试者被双盲随机分为乙酰唑胺组或安慰剂组。在攀登至4846米并停留6晚期间，对血气、2,3-二磷酸甘油酸（2,3 DPG）、蛋白尿、运动测试、肠道吸收、嘌呤代谢以及身体成分变化进行了研究。结果显示，乙酰唑胺对运动表现和肌肉量的维持有有益作用。
