伏安法测定作为治疗新冠肺炎抗病毒药物的法匹拉韦在铅笔石墨电极上的含量
Voltammetric Determination of Favipiravir Used as an Antiviral Drug for the Treatment of Covid-19 at Pencil Graphite Electrode.
作者信息
Erşan Teslime, Dilgin Didem Giray, Kumrulu Elif, Kumrulu Umur, Dilgin Yusuf
机构信息
Faculty Science Department of Chemistry Çanakkale Onsekiz Mart University 17100 Turkey Çanakkale.
Department of Mathematics and Science Education Faculty of Education Çanakkale Onsekiz Mart University Çanakkale Turkey.
出版信息
Electroanalysis. 2022 Nov 16. doi: 10.1002/elan.202200295.
Abstract
This work describes the sensitive voltammetric determination of favipiravir (FAV) based on its reduction for the first time with a low-cost and disposable pencil graphite electrode (PGE). In addition, the determination of FAV was also performed based on its oxidation. Differential pulse (DP) voltammograms recorded in 0.5 M HSO for the reduction of FAV show that peak currents increase linearly in the range of 1.0 to 600.0 μM with a limit of detection of 0.35 μM. The acceptable recovery values (98.9-106.0 %) obtained from a pharmaceutical tablet, real human urine, and artificial blood serum samples spiked with FAV confirm the high accuracy of the proposed method.
摘要
这项工作首次描述了基于法匹拉韦（FAV）还原反应，使用低成本一次性铅笔石墨电极（PGE）对其进行灵敏的伏安测定。此外，还基于法匹拉韦的氧化反应进行了测定。在0.5 M硫酸中记录的法匹拉韦还原反应的差分脉冲（DP）伏安图表明，在1.0至600.0 μM范围内，峰电流呈线性增加，检测限为0.35 μM。从添加了法匹拉韦的药片片剂、真实人尿液和人工血清样品中获得的可接受回收率值（98.9 - 106.0%）证实了所提出方法的高准确性。
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