Hippo信号通路在铁死亡中的作用。

Xiang Jiangxia, Jiang Mengmeng, Du Xing

Department of Traumatology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.

Department of Medical Oncology, The Third Central Hospital of Tianjin, Tianjin, China.

Front Oncol. 2023 Jan 11;12:1107505. doi: 10.3389/fonc.2022.1107505. eCollection 2022.

The role of Hippo pathway in ferroptosis The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), and is closely related to cell growth, survival, proliferation, and migration; tissue and organ size control; and tumorigenesis and development. Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of oxidation and the antioxidant system. This article elaborates the role of Hippo pathway in ferroptosis, providing ideas for the regulation of cell fate and the treatment of tumors.

河马通路在铁死亡中的作用河马通路主要由哺乳动物丝氨酸/苏氨酸（Ste20）样激酶1/2（MST1/2）、大肿瘤抑制因子1/2（LATS1/2）和转录共激活因子Yes相关蛋白（YAP）组成，与细胞生长、存活、增殖和迁移密切相关；组织和器官大小控制；以及肿瘤发生和发展。铁死亡是一种受调控的细胞死亡形式，其特征是铁依赖性活性氧（ROS）的积累和质膜多不饱和脂肪酸（PUFA）的消耗，这是由氧化和抗氧化系统失衡引起的。本文阐述了河马通路在铁死亡中的作用，为细胞命运调控和肿瘤治疗提供思路。