Zhang Ting, Cui Xiao-Mei, Zhang Yu-Ying, Xie Tao, Deng Yuan-Jia, Guo Fang-Xi, Wang Qi, Wu Qing-Feng, Dong Ming-Hua, Luo Xiao-Ting
Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, China.
School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.
Front Psychiatry. 2023 Jan 11;13:989492. doi: 10.3389/fpsyt.2022.989492. eCollection 2022.
Previous studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms. We aimed to investigate the relationship between inflammation and depressive symptoms at different levels of dietary fiber intake and to explore whether dietary fiber affects depression through inflammation.
A total of 8,430 National Health and Nutrition Examination Survey (NHANES) samples were collected between 2015 and 2018. Factor analysis was used to determine dietary patterns. Linear regression and logistic regression analysis were used to explore the relationship between nutrients, inflammation, and depressive symptoms, and the mediation analysis was conducted using the bootstrap method.
Factor 3 (dietary fiber and vitamins) was inversely associated with depressive symptoms and inflammation. The upper quartile scores of the dietary inflammatory index (DII) and C-reactive protein (CRP) were associated with depressive symptoms compared with controls (DII: = 1.851, 95% CI: 1.267-2.705; CRP: = 1.737, 95% CI: 1.136-2.656). The DII score and CRP were associated with depressive symptoms in the group with low dietary fiber intake (DII: = 2.736, 95% CI: 1.628-4.598; CRP: = 2.092, 95% CI: 1.196-3.658) but not in the high dietary fiber intake group. Mediating analysis showed that CRP partially mediated the effect of dietary fiber intake on depressive symptoms (β = -0.0025, 95% CI: -0.0038 to -0.0013), and the mediated proportion was 10.5%.
In this study, we found that DII scores and CRP were not associated with depressive symptoms in participants with high dietary fiber intake, and inflammation partially mediates the effect of dietary fiber on depressive symptoms.
既往研究表明炎症会影响抑郁症状。膳食纤维可能与炎症及抑郁症状有关。我们旨在研究不同膳食纤维摄入水平下炎症与抑郁症状之间的关系，并探讨膳食纤维是否通过炎症影响抑郁。
2015年至2018年期间共收集了8430份美国国家健康与营养检查调查（NHANES）样本。采用因子分析确定饮食模式。使用线性回归和逻辑回归分析探讨营养素、炎症与抑郁症状之间的关系，并采用自抽样法进行中介分析。
因子3（膳食纤维和维生素）与抑郁症状及炎症呈负相关。与对照组相比，饮食炎症指数（DII）和C反应蛋白（CRP）的上四分位数得分与抑郁症状相关（DII：=1.851，95%置信区间：1.267 - 2.705；CRP：=1.737，95%置信区间：1.136 - 2.656）。在膳食纤维摄入量低的组中，DII得分和CRP与抑郁症状相关（DII：=2.736，95%置信区间：1.628 - 4.598；CRP：=2.092，95%置信区间：1.196 - 3.658），但在高膳食纤维摄入量组中则不然。中介分析表明，CRP部分介导了膳食纤维摄入量对抑郁症状的影响（β = -0.0025，95%置信区间：-0.0038至-0.0013），中介比例为10.5%。
在本研究中，我们发现膳食纤维摄入量高的参与者中，DII得分和CRP与抑郁症状无关，且炎症部分介导了膳食纤维对抑郁症状的影响。
